Departmental Papers (Dental)

 
Penn Dental Medicine views scholarship as a central component of excellence in instruction and patient care and places a high priority on research. The School’s research enterprise spans scientific disciplines to translate new knowledge into clinical therapies that positively impact our understanding of oral disease and advance patient care.

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Submissions from 2018

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Ameloblastoma: Current Etiopathological Concepts and Management, O. A. Effiom, O. M. Ogundana, A. O. Akinshipo, and S. O. Akintoye

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Robust Lysosomal Calcium Signaling Through Channel TRPML1 is Impaired by Lysosomal Lipid Accumulation, Nestor Mas Gomez, Wennan Lu, Jason C. Lim, Kirill Kiselyov, Keith E. Campagno, Yulia Campagno, Susan A. Slaugenhaupt, Bruce A. Pfeffer, Steven J. Fliesler, and Claire H. Mitchell

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Underdeveloped RPE Apical Domain Underlies Lesion Formation in Canine Bestrophinopathies, Karina E. Guziewicz, Emily McTish, Valerie L. Dufour, Kathryn Zorych, Anuradha Dhingra, Kathleen Boesze-Battaglia, and Gustavo D. Aguirre

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Fibromodulin Reduces Scar Size and Increases Scar Tensile Strength in Normal and Excessive-Mechanical-Loading Porcine Cutaneous Wounds, Wenlu Jiang, Kang Ting, Soonchul Lee, Janette N. Zara, Richard Song, Chenshuang Li, Eric Chen, Xinli Zhang, Zhihe Zhao, Chia Soo, and Zhong Zheng

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Methodological Quality Assessment of Meta-analyses in Endodontics, Sereen Kattan, Su-Min Lee, Meetu R. Kohli, Frank C. Setzer, and Bekir Karabucak

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The Fas/Fap-1/Cav-1 complex regulates IL-1RA secretion in mesenchymal stem cells to accelerate wound healing, Xiaoxing Kou, Xingtian Xu, Chider Chen, Maria Laura Sanmillan, Tao Cai, Yanheng Zhou, Claudio Girauda, Anh Le, and Songtao Shi

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Expression and Assembly of Largest Foreign Protein in Chloroplasts: Oral Delivery of Human FVIII Made in Lettuce Chloroplasts Robustly Suppresses Inhibitor Formation in Haemophilia A Mice, Kwang‐Chul Kwon, Alexandra Sherman, Wan‐Jung Chang, Aditya Kamesh, Moanaro Biswas, Roland W. Herzog, and Henry Daniell

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Neurexin Superfamily Cell Membrane Receptor Contactin-Associated Protein Like-4 (Cntnap4) Is Involved in Neural EGFL-Like 1 (Nell-1)-Responsive Osteogenesis, Chenshuang Li, Zhong Zheng, Pin Ha, Xiaoyan Chen, Wenlu Jiang, Shan Sun, Feng Chen, Greg Asatrian, Emily A. Berthiaume, Jong Kil Kim, Eric C. Chen, Shen Pang, Xinli Zhang, Kang Ting, and Chia Soo

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Neural EGFL-Like 1 Regulates Cartilage Maturation through Runt-Related Transcription Factor 3–Mediated Indian Hedgehog Signaling, Chenshuang Li, Zhong Zheng, Jie Jiang, Wenlu Jiang, Kevin Lee, Emily A. Berthiaume, Eric C. Chen, Cymbeline T. Culiat, Yan-Heng Zhou, Xinli Zhang, Kang Ting, and Chia Soo

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Nfatc1 Is a Functional Transcriptional Factor Mediating Nell-1-Induced Runx3 Upregulation in Chondrocytes, Chenshuang Li, Zhong Zheng, Xinli Zhang, Greg Asatrian, Eric Chen, Richard Song, Cymbeline Culiat, Kang Ting, and Chia Soo

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Topical Ferumoxytol Nanoparticles Disrupt Biofilms and Prevent Tooth Decay in Vivo Via Intrinsic Catalytic Activity, Y. Liu, P. C. Naha, G. Hwang, D. Kim, Huang Y., A. Simon-Soro, H. I. Jung, Z. Ren, Y. Li, S. Gubara, F. Alawi, D. Zero, A. T. Hara, D. P. Cormode, and H. Koo

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The P2Y12 Receptor Antagonist Ticagrelor Reduces Lysosomal pH and Autofluorescence in Retinal Pigmented Epithelial Cells From the ABCA4-/- Mouse Model of Retinal Degeneration, Wennan Lu, Néstor M. Gómez, Jason C. Lim, Sonia Guha, Ann O'Brien-Jenkins, Erin E. Coffey, Keith E. Campagno, Stuart A. McCaughey, Alan M. Laties, Leif G. Carlsson, and Claire H. Mitchell

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Upregulation of Mas-Related G Protein Coupled Receptor X2 in Asthmatic Lung Mast Cells and its Activation by the Novel Neuropeptide Hemokinin-1, W. Manorak, C. Idahosa, K. Gupta, T. Jahan, and H. Ali

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CALHM3 Is Essential for Rapid Ion Channel-Mediated Purinergic Neurotransmission of GPCR-Mediated Tastes, Zhongming Ma, Akiyuki Taruno, Makoto Ohmoto, Masafumi Jyotaki, Jason C. Lim, Hiroaki Miyazaki, Naomi Niisato, Yoshinori Marunaka, Robert J. Lee, Henry Hoff, Riley Payne, Angelo Demuro, Ian Parker, Claire H. Mitchell, Jorge Henao-Mejia, Jessica E. Tanis, Ichiro Matsumoto, Michael G. Tordoff, and Kevin J. Foskett

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Compromised Phagosome Maturation Underlies RPE Pathology in Cell Culture and Whole Animal Models of Smith-Lemli-Opitz Syndrome, Sriganesh Ramachandra Rao, Bruce A. Pfeffer, Néstor Más Gómez, Lara A. Skelton, Ueda Keiko, Janet R. Sparrow, Aryn M. Rowsam, Claire H. Mitchell, and Steven J. Fliesler

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Current Development of Biodegradable Polymeric Materials for Biomedical Applications, Richard Song, Maxwell Murphy, Chenshuang Li, Kang Ting, Chia Soo, and Zhong Zheng

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Ecological Balance of Oral Microbiota is Required to Maintain Oral Mesenchymal Stem Cell Homeostasis, Yingying Su, Chider Chen, Lijia Guo, Juan Du, Xiaoyan Li, and Yi Liu

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The Fas/Fap-1/Cav-1 Complex Regulates IL-1RA Secretion in Mesenchymal Stem Cells to Accelerate Wound Healing, Yingying Su, Chider Chen, Lijia Guo, Juan Du, Xiaoyan Li, and Yi Liu

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High Efficient Multisites Genome Editing in Allotetraploid Cotton (Gossypium Hirsutum) Using CRISPR/Cas9 System, Pengcheng Wang, Jun Zhang, Lin Sun, Yizan Ma, Jiao Xu, Sijia Liang, Qinghua Zhang, Lili Tu, Henry Daniell, Shuangxia Jin, and Xianlong Zhang

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RANKL Deletion in Periodontal Ligament and Bone Lining Cells Blocks Orthodontic Tooth Movement, Chia-Ying Yang, Hyeran H. Jeon, Ahmed Alshabab, Yu Jin Lee, and Chun-Hsi Chung

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3D Bio-printed Scaffold-free Nerve Constructs with Human Gingiva-derived Mesenchymal Stem Cells Promote Rat Facial Nerve Regeneration, Qunzhou Zhang, Phuong D. Nguyen, Shihong Shi, Justin C. Burrell, Kacy D. Cullen, and Anh D. Le

Submissions from 2017

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Hydrogel Elasticity and Microarchitecture Regulate Dental-Derived Mesenchymal Stem Cells -Host Immune System Cross-Talk, Sahar Ansari, Chider Chen, Mohammad Mahdi Hasani-Sarabadi, Bo Yu, Homayoun H. Zadeh, Benjamin M. Wu, and Alireza Moshaverinia

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Human Periodontal Ligament- and Gingiva-derived Mesenchymal Stem Cells Promote Nerve Regeneration When Encapsulated in Alginate/hyaluronic Acid 3D Scaffold, Sahar Ansari, Ivana D. Diniz, Chider Chen, Patricia Sarrion, Ali Tamayol, Benjamin M. Wu, and Alireza Moshaverinia

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Dental and Orofacial Mesenchymal Stem Cells in Craniofacial Regeneration: a Prosthodontist’s Point of View, Sahar Ansari, Jackson T. Seagroves, Chider Chen, Kumar Shah, Tara Aghaloo, Benjamin M. Wu, Sompop Bencharit, and Alireza Moshaverinia

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Internalization of the Active Subunit of the Aggregatibacter Actinomycetemcomitans Cytolethal Distending Toxin Is Dependent upon Cellugyrin (Synaptogyrin 2), a Host Cell Non-Neuronal Paralog of the Synaptic Vesicle Protein, Synaptogyrin 1, Kathleen Boesze-Battaglia, Lisa P. Walker, Anuradha Dhingra, Konstantin Kandror, Hsin-Yao Tang, and Bruce J. Shenker

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Internalization of the Active Subunit of the Aggregatibacter Actinomycetemcomitans Cytolethal Distending Toxin Is Dependent Upon Cellugyrin (Synaptogyrin 2), a Host Cell Non-Neuronal Paralog of the Synaptic Vesicle Protein, Synaptogyrin 1, Kathleen Boesze-Battaglia, Lisa P. Walker, Anuradha Dhingra, Konstantin Kandror, Hsin-Yao Tang, and Bruce J. Shenker

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The Bone Regenerative Capacity of Canine Mesenchymal Stem Cells is Regulated by Site-Specific Multilineage Differentiation, J. Bugueño, W. Li, P. Salat, L. Qin, and S. O. Akintoye

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Canine Mesenchymal Stem Cell Bone Regenerative Capacity is Regulated by Site-Specific Multi-Lineage Differentiation, Juan Bugueno, Weihua Li, Pinky Salat, Ling Qin, and Sunday O. Akintoye

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PBJ is Now a Leading Open Access Plant Journal, Henry Daniell

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Subgingival Microbiota Dysbiosis in Systemic Lupus Erythematosus: Association with Periodontal Status, Jôice Dias Corrêa, Débora Cerqueira Calderaro, Gilda Aparecida Ferreira, Santuza Maria Souza Mendonça, Gabriel R. Fernandes, E Xiao, Antônio Lúcio Teixeira, Eugene J. Leys, Dana T. Graves, and Tarcília Aparecida Silva

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FOXO1 Regulates Bacteria-Induced Neutrophil Activity, Guangyu Dong, Liang Song, Chen Tian, Yu Wang, Fang Miao, Jiabao Zheng, Chanyi Lu, Sarah Alsadun, and Dana T. Graves

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Loss of Notch3 Signaling Enhances Osteogenesis of Mesenchymal Stem Cells from Mandibular Torus, X W. Dou, W Park, S Lee, Q Z. Zhang, L R. Carrasco, and A D. Le

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Differential Regulation of Mas-Related G Protein-Coupled Receptor X2- Mediated Mast Cell Degranulation by Antimicrobial Host Defense Peptides and Porphyromonas Gingivalis Lipopolysaccharide, Kshitij Gupta, Chizobam Idahosa, Saptarshi Roy, Donguk Lee, Hariharan Subramanian, Anuradha Dhingra, Kathleen Boesze-Battaglia, Jonathan Korostoff, and Hydar Ali

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Bestrophinopathy: An RPE-Photoreceptor Interface Disease, Karina E. Guziewicz, Divya Sinha, Néstor M. Gómez, Kathryn Zorych, Emily V. Dutrow, Anuradha Dhingra, Robert F. Mullins, Edwin M. Stone, David M. Gamm, and Kathleen Boesze-Battaglia

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Mesenchymal Stromal Cell-Derived Interleukin-6 Promotes Epithelial–Mesenchymal Transition and Acquisition of Epithelial Stem-Like Cell Properties in Ameloblastoma Epithelial Cells, jChunmiao Jiang, Qunzhou Zhang, Rabie M. Shanti, Shihong Shi, Ting-Han Chang, Lee Carrasco, Faizan Alawi, and Anh D. Le

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IL-36 Induces Bisphosphonate-Related Osteonecrosis of the Jaw-Like Lesions in Mice by Inhibiting TGF-β-Mediated Collagen Expression, Sol Kim, Drake W. Williams, Cindy Williams, Terresa Kim, Atsushi Arai, Songtao Shi, Xinmin Li, Ki-Hyuk Shin, Mo K. Kang, No-Hee Park, and Reuben H. Kim

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Neural EGFL-Like 1 Is a Downstream Regulator of Runt-Related Transcription Factor 2 in Chondrogenic Differentiation and Maturation, Chenshuang Li, Jie Jiang, Zhong Zheng, Kevin S. Lee, Yanheng Zhou, Eric Chen, Cymbeline T. Culiat, Yiqiang Qiao, Xuepeng Chen, Kang Ting, Xinli Zhang, and Chia Soo

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TNFα Contributes to Diabetes Impaired Angiogenesis in Fracture Healing, Jason C. Lim, Kang I. Ko, Marcelo Mattos, Miao Fang, Citong Zhang, Daniel Feinberg, Hisham Sindi, Shuai Li, Jazia Alblowi, Rayyan A. Kayal, Thomas A. Einhorn, Louis Gerstenfeld, and Dana Graves

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Chemical and Radiation-Associated Jaw Lesions, Temitope T. Omolehinwa Dr. and Sunday O. Akintoye Dr.

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Phagocytosis-Dependent Ketogenesis in Retinal Pigment Epithelium, Juan Reyes-Reveles, Anuradha Dhingra, Desiree Alexander, Alvina Bragin, Nancy J. Philp, and Kathleen Boesze-Battaglia

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Phagocytosis-Dependent Ketogenesis in Retinal Pigment Epithelium, Juan Reyes-Reveles, Anuradha Dhingra, Desiree Alexander, Alvina Bragin, Nancy J. Philp, and Kathleen Boesze-Battaglia

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Exploring the Microbiome of Healthy and Diseased Peri-Implant Sites Using Illumina Sequencing, I. Sanz-Martin, J. Doolittle-Hall, R. P. Teles, M. Pate, G. N. Belibasakis, C. H. Hämmerle, R. E. Jung, and F. R.F. Teles

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CALHM1-Mediated ATP Release and Ciliary Beat Frequency Modulation in Nasal Epithelial Cells, Alan D. Workman, Ryan M. Carey, Bei Chen, Cecil J. Saunders, Philippe Marambaud, Claire H. Mitchell, Michael G. Tordoff, Robert J. Lee, and Noam A. Cohen

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Long-Term Evaluation of Mucosal and Systemic Immunity and Protection Conferred by Different Polio Booster Vaccines, Yuhong Xiao and Henry Daniell

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Progesterone Attenuates Temporomandibular Joint Inflammation Through Inhibition of NF-κB Pathway in Ovariectomized Rats, Xin-Tong Xue, Xiao-Xing Kou, Chen-Shuang Li, Rui-Yun Bi, Zhen Meng, Xue-Dong Wang, Yan-Heng Zhou, and Ye-Hua Gan

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A Gingiva-Derived Mesenchymal Stem Cell-Laden Porcine Small Intestinal Submucosa Extracellular Matrix Construct Promotes Myomucosal Regeneration of the Tongue, Qilin Xu, Rabie M. Shanti, Qunshou Zhang, Steven B. Cannady, Bert W. O'Malley, and C D. Chen

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EGF Induces Epithelial-mesenchymal Transition and Cancer Stem-like Cell Properties in Human Oral Cancer Cells via Promoting Warburg Effect, Qilin Xu, Qunzhou Zhang, Yasutaka Ishida, Souren Jajjar, Xudong Tang, Haoran Shi, Chi V. Dang, and Anh D. Le

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Expression and Functional Evaluation of Biopharmaceuticals Made in Plant Chloroplasts, Bei Zhang, Balamurugan Shanmugaraj, and Henry Daniell

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Expression and Functional Evaluation of Biopharmaceuticals Made in Plant Chloroplasts, Bei Zhang, Balamurugan Shanmugaraj, and Henry Daniell

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FOXO1 Deletion in Keratinocytes Improves Diabetic Wound Healing through MMP9 Regulation, Chenying Zhang, Jason Lim, Hyeran H. Jeon, Fanxing Xu, Chen Tian, Fang Miao, Alhassan Hameedaldeen, and Dana T. Graves

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FOXO1 Expression in Keratinocytes Promotes Connective Tissue Healing, Chenying Zhang, Jason Lim, Jian Liu, Bhaskar Ponugoti, Sarah Alsadun, Chen Tian, Rameen Vafa, and Dana T. Graves

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Neural Progenitor-like Cells Induced from Human Gingiva-derived Mesenchymal Stem Cells Regulate Myelination of Schwann Cells in Rat Sciatic Nerve Regeneration, Qunzhou Zhang, Phuong Nguyen, Qilin Xu, Wonse Park, Sunim Lee, Akihiro Furuhashi, and Anh D. Le

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Fibromodulin Reduces Scar Formation in Adult Cutaneous Wounds by Eliciting a Fetal-Like Phenotype, Zhong Zheng, Aaron W. James, Chenshuang Li, Wenlu Jiang, Joyce Z. Wang, Grace X. Chang, Kevin S. Lee, Feng Chen, Emily A. Berthiaume, Yao Chen, Hsin Chuan Pan, Eric C. Chen, Weiming Li, Zhihe Zhao, Xinli Zhang, Kang Ting, and Chia Soo

Submissions from 2016

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Toxicities and Early Outcomes in a Phase 1 Trial of Photodynamic Therapy For Premalignant and Early Stage Head and Neck Tumors, Peter H. Ahn, Harry Quon, Burt W. O'Malley, Gregory Weinstein, Ara Chalian, Kelly Malloy, Joshua H. Atkins, Thomas Sollecito, Martin Greenberg, Sally McNulty, Alexander Lin, Timothy C. Zhu, Jarod C. Finlay, Keith Cengal, Virginia Livolsi, Michael Feldman, Rosemarie Mick, and Theresa M. Busch

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Impact of Communication Between Physicians and Dentists on the Incidence of Jaw Osteonecrosis Caused by Bone Anti-Resorptives, Sunday O. Akintoye and Elliot V. Hersh

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Muscle Tissue Engineering Using Gingival Mesenchymal Stem Cells Encapsulated in Alginate Hydrogels Containing Multiple Growth Factors, Sahar Ansari, Chider Chen, Xingtian Xu, Nasim Annabi, Homayoun H. Zadeh, Benjamin M. Wu, Ali Khademhosseini, and Alireza Moshaverinia

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Muscle Tissue Engineering Using Gingival Mesenchymal Stem Cells Encapsulated in Alginate Hydrogels Containing Multiple Growth Factors, Sahar Ansari, Chider Chen, Xingtian Xu, Nasim Annabi, Homayoun H. Zadeh, Benjamin M. Wu, Ali Khademhosseini, Songtao Shi, and Alireza Moshaverinia

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Aggregatibacter actinomycetemcomitans leukotoxin induces cytosol acidification in LFA-1 expressing immune cells, N. Balashova, A. Dhingra, K. Boesze-Battaglia, and E. T. Lally

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A Journey of Cytolethal Distending Toxins Through Cell Membranes, Kathleen Boesze-Battaglia, Desiree Alexander, Mensur Dlakić, and Bruce J. Shenker

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A Journey of Cytolethal Distending Toxins Through Cell Membranes, Kathleen Boesze-Battaglia, Desiree Alexander, Mensur Dlakić, and Bruce J. Shenker

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Inhibition of LtxA Toxicity by Blocking Cholesterol Binding with Peptides, A. C. Brown, E. Koufos, E. Koufos, N. V. Balashova, Kathleen Boesze-Battaglia, and E. T. Lally

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Inhibition of LtxA Toxicity by Blocking Cholesterol Binding With Peptides, Angela C. Brown, Evan Koufos, Nataliya Balashova, Edward T. Lally, Nataliya Balashova, Kathleen Boesze-Battaglia, and Edward T. Lally

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Cold Chain and Virus‐Free Chloroplast‐Made Booster Vaccine to Confer Immunity Against Different Poliovirus Serotypes, Hui‐Ting Chan, Yuhong Xiao, William C. Weldon, Steven M. Oberste, Konstantin Chumakov, and Henry Daniell

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Chloroplast Genomes: Diversity, Evolution, and Applications in Genetic Engineering, Henry Daniell, Choun-Sea Lin, Ming Yu, and Wan-Jung Chang

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Diabetes and Increased Lipid Peroxidation are Associated with Systemic Inflammation Even in Well-Controlled Patients, Alliny de Souza Bastos, Dana T. Graves, Ana Paula de Melo Louireiro, Carlos Rossa Jr, Samia Cruz Tfaile Corbi, Fausto Frizzera, Raquel Mantuaneli Scarel-Caminaga, Niels Olsen-Camara, Oelisoa M. Andriankaja, Meire I. Hiyane, and Silvana Regina Perez Orrico

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Gingival Mesenchymal Stem Cell (GMSC) Delivery System Based on RGD-Coupled Alginate Hydrogel with Antimicrobial Properties: A Novel Treatment Modality for Peri-Implantitis, Ivana M. A. Diniz, Chider Chen, Sahar Ansari, Homayoun H. Zadeh, Maryam Moshaverinia, Daniel Chee, Márcia M. Marques, Songtao Shi, and Alireza Moshaverinia

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Gingival Mesenchymal Stem Cell (GMSC) Delivery System Based on RGD-Coupled Alginate Hydrogel with Antimicrobial Properties: A Novel Treatment Modality for Peri-Implantitis, Ivana M.A. Diniz, Chider Chen, Sahar Ansari, Homayoun H. Zadeh, Maryam Moshaverinia, Daniel Chee, Márcia M. Marques, Songtao Shi, and Alireza Moshaverinia

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Nanoindentation Modulus of Murine Cartilage: A Sensitive Indicator of the Initiation and Progression of Post-Traumatic Osteoarthritis, Basak Doyran, Wei Tong, Qing Li, Haoruo Jia, Xianrong Zhang, Chider Chen, Motomi Enomoto-Iwamoto, X. Lucas Lu, Ling Qin, and Lin Han

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The Subgingival Periodontal Microbiota in the Aging Mouth, Magda Feres, Flavia Teles, Ricardo Teles, Luciene Cristina Figueiredo, and Marcelo Faveri

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Modulation of Host Defense Peptide-Mediated Human Mast Cell Activation by LPS, K. Gupta, H. Subramanian, and H. Ali

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Microbial Ecosystem Analysis in Root Canal Infections Refractory to Endodontic Treatment, Luiz Carlos Feitosa Henriques, Luciana Carla Neves de Brito, Warley Luciano Faria Tavares, Ricardo Palmier Teles, Leda Quercia Vieira, Flavia Rodrigues Teles, and Antonio Paulino Ribiero Sobrinho

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Alcohol-Induced Suppression of KDM6B Dysregulates the Mineralization Potential in Dental Pulp Stem Cells, Michael Hoang, Jeffrey J. Kim, Yiyoung Kim, Elizabeth Tong, Benjamin Trammell, Yao Liu, Songtao Shi, Chang-Ryul Lee, Christine Hong, Cun-Yu Wang, and Yong Kim

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Penn Endo Surgical Documentation Guidelines, Bekir Karabucak

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Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (3rd edition), Daniel J. Klionsky, Kotb Abdelmohsen, Md Joynal Abedin, Akihisa Abe, and Akihisa

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Nanofibrous Spongy Microspheres for the Delivery of Hypoxia-primed Human Dental Pulp Stem Cells to Regenerate Vascularized Dental Pulp, Rong Kuang, Zhanpeng Zhang, Xiaobing Jin, Jiang Hu, Songtao Shi, Longxing Ni, and Peter X. Ma

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Oral Delivery of Protein Drugs Bioencapsulated in Plant Cells, Kwang-Chul Kwon and Henry Daniell

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DPSCs from Inflamed Pulp Modulate Macrophage Function via the TNF-α/IDO Axis, S Lee, Q Z. Zhang, B Karabucak, and A D. Le

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Biocompatibility of two Experimental Scaffolds for Regenerative Endodontics, Dephne Jack Xin Leong, Frank Setzer, Martin Trope, and Bekir Karabucak

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Fibromodulin Reprogrammed Cells: A Novel Cell Source for Bone Regeneration, Chen-Shuang Li, Pu Yang, Kang Ting, Tara Aghaloo, Soonchul Lee, Yulong Zhang, Kambiz Khalilinejad, Maxwell C. Murphy, Hsin Chuan Pan, Xinli Zhang, Benjamin Wu, and Yan-Heng Zhao

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Accelerated Chondrogenic Differentiation of Human Perivascular Stem Cells with NELL-1, Chen-Shuang Li, Xinli Zhang, Bruno Péault, Jie Jiang, Kang Ting, Chia Soo, and Yan-Heng Zhou

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Activation of the Extracellular Signal-Regulated Kinase Signaling Is Critical for Human Umbilical Cord Mesenchymal Stem Cell Osteogenic Differentiation, Chen-Shuang Li, Zhong Zheng, Xiao-Xia Su, Fei Wang, Michelle Ling, Min Zou, and Hong Zhou

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Transcriptome Analysis Reveals a Comprehensive Insect Resistance Response Mechanism in Cotton to Infestation by the Phloem Feeding Insect Bemisia Tabaci (Whitefly), Jianying Li, Lizhen Zhu, J. Joe Hull, Sijia Liang, Henry Daniell, Shuangxia Jin, and Xianlong Zhang

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Topical Delivery of Low-Cost Protein Drug Candidates Made in Chloroplasts for Biofilm Disruption and Uptake by Oral Epithelial Cells, Yuan Liu, Aditya C. Kamesh, Yuhong Xiao, Victor Sun, and Michael Hayes

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Compartmentalized Metabolic Engineering for Artemisinin Biosynthesis and Effective Malaria Treatment by Oral Delivery of Plant Cells, Karan Malhotra, Mayavan Subramaniyan, Khushboo Rawat, Md. Kalamuddin, M. Irfan Qureshi, Pawan Malhotra, Asif Mohmmed, Katrina Cornish, Henry Daniell, and Shashi Kumar

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From Orphan Drugs to Adopted Therapies: Advancing C3-Targeted Intervention to the Clinical Stage, Dimitrios C. Mastellos, Edimara S. Reis, Despina Yancopoulou, George Hajishengallis, Daniel Ricklin, and John D. Lambris

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Chemical and Radiation Associated Jaw Lesions, Temitope T. Omolehinwa and Sunday O. Akintoye

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Chemical and Radiation Associated Jaw Lesions, Temitope T. Omolehinwa and Sunday O. Akintoye

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Incidental Finding of an Extensive Oropharyngeal Mass in Magnetic Resonance Imaging of a Patient With Temporomandibular Disorder: A Case Report, Temitope T. Omolehinwa, Mel Mupparapu, and Sunday O. Akintoye

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Terpene Metabolic Engineering Via Nuclear or Chloroplast Genomes Profoundly and Globally Impacts Off‐Target Pathways Through Metabolite Signalling, Elise K. Pasoreck, Jin Su, Ian M. Silverman, Sager J. Gosai, and Brian D. Gregory

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The Cytolethal Distending Toxin Contributes to Microbial Virulence and Disease Pathogenesis by Acting as a Tri-Perditious Toxin, Monika D. Scuron, Kathleen Boesze-Battaglia, Mensur Dlakic, and Bruce J. Shenker

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Plant‐Based Oral Vaccines Against Zoonotic and Non‐Zoonotic Diseases, Naila Shahid and Henry Daniell

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The Toxicity of the Aggregatibacter Actinomycetemcomitans Cytolethal Distending Toxin Correlates With its Phosphatidylinositol-3,4,5-Triphosphate Phosphatase Activity, Bruce J. Shenker, Kathleen Boesze-Battaglia, Monika Damek Scuron, Lisa P. Walker, Ali Zekavat, and Mensur Dlakić

Lymphoid Susceptibility to the Aggregatibacter Actinomycetemcomitans Cytolethal Distending Toxin (Cdt) is Dependent Upon Baseline Levels of the Signaling Lipid, Phosphatidylinositol-3,4,5-Triphosphate, Bruce J. Shenker, Lisa P. Walker, Ali Zekavat, and Kathleen Boesze-Battaglia

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Expression of Beta-Glucosidase Increases Trichome Density and Artemisinin Content in Transgenic Artemisia Annua Plants, Nameirakpam Dolendro Singh, Shashi Kumar, and Henry Daniell

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Gingival Swelling Associated with Hypoplasminogenemia, Eric T. Stoopler and Faizan Alawi

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Roles of Mas-Related G Protein–Coupled Receptor X2 on Mast Cell–Mediated Host Defense, Pseudoallergic Drug Reactions, and Chronic Inflammatory Diseases, H. Subramanian, K. Gupta, and H. Ali

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Experimental and Finite Element Study of Residual Thermal Stresses in Veneered Y-TZP Structures, Carina B. Tanaka, Hossam Harisha, Marta Baldassarri, Mark S. Wolff, Hui Tong, Josete B.C. Meira, and Yu Zhang

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NF-κB has a Direct Role in Inhibiting Bmp- and Wnt-Induced Matrix Protein Expression., Rohinton S. Tarapore, Jason Lim, Chen Tian, Sandra Pacios, Wenmei Xiao, Daniel Reid, Hancheng Guan, Marcelo Mattos, Bo Yu, Cun-Yu Wang, and Dana T. Graves

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Low Cost Delivery of Proteins Bioencapsulated in Plant Cells to Human Non-Immune or Immune Modulatory Cells, Yuhong Xiao, Kwang-Chul Kwon, Brad E. Hoffman, Aditya Kamesh, Noah T. Jones, Roland T. Herzog, and Henry Daniell

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Wnt/β-Catenin Signaling Determines the Vasculogenic Fate of Post-Natal Mesenchymal Stem Cells, Zhaocheng Zhang, Felipe Nor, Min Oh, Carolina Cucco, Songtao Shi, and Jacques E. Nör