Porphyromonas gingivalis-Host Interactions: Open War or Intelligent Guerilla Tactics?
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Departmental Papers (Dental)
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P. gingivalis
host-pathogen interactions
innate immunity
inflammation
immune evasion
Dentistry
host-pathogen interactions
innate immunity
inflammation
immune evasion
Dentistry
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Hajishengallis, George
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Abstract
This review summarizes and discusses virulence mechanisms whereby Porphyromonas gingivalis can persist in the oral cavity. It is proposed that that the virulence of P. gingivalis is dependent, at least in part, upon its ability to establish a complex host-pathogen molecular crosstalk which subverts innate immunity. The sophisticated stealth and sabotage tactics used by P. gingivalis may additionally benefit co-habiting organisms occupying the same niche
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2009-01-01
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Microbes and Infection
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At the time of publication, author George Hajishengallis was affiliated with the University of Louisville Health Sciences Center. Currently, he is a faculty member at the School of Dental Medicine at the University of Pennsylvania.