Departmental Papers (Dental)

Document Type

Journal Article

Date of this Version

2-2013

Publication Source

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

Volume

115

Issue

2

Start Page

201

Last Page

211

DOI

10.1016/j.oooo.2012.09.008

Abstract

Abstract

Objectives

Osteoradionecrosis (ORN) is common in the jaws following radiotherapy. We hypothesized that mandible is more susceptible to ORN than tibia based on site-disparity in hypoxic-hypocellular-hypovascular tissue breakdown.

Study Design

Twelve rats received 50 Gy irradiation to mandible or tibia; 4 of 12 rats further received minor surgical trauma to the irradiated sites. Structural and cellular skeletal changes were assessed with computer tomography, histology and immunostaining.

Results

Mandible developed ORN with 70% mean bone loss 10 weeks post-irradiation (p < 0.05) while tibia was structurally and radiological intact for 20 weeks post-irradiation. Hypocellularity, hypoxia and oxidative stress were higher in irradiated mandible (p < 0.001) than tibia (p < 0.01) but vascular damage was similar at both skeletal sites. Combined effects of radiation and minor trauma promoted mandibular alveolar bone loss and tibial fracture

Conclusion

ORN has a more rapid onset in mandible relative to tibia in the rat

Copyright/Permission Statement

This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/

Keywords

Osteoradionecrosis, Hypovascular, Hypocellular, Radiotherapy, Oxidative stress, Animal model

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Date Posted: 10 August 2018

This document has been peer reviewed.