Departmental Papers (Dental)
Date of this Version
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Osteoradionecrosis (ORN) is common in the jaws following radiotherapy. We hypothesized that mandible is more susceptible to ORN than tibia based on site-disparity in hypoxic-hypocellular-hypovascular tissue breakdown.
Twelve rats received 50 Gy irradiation to mandible or tibia; 4 of 12 rats further received minor surgical trauma to the irradiated sites. Structural and cellular skeletal changes were assessed with computer tomography, histology and immunostaining.
Mandible developed ORN with 70% mean bone loss 10 weeks post-irradiation (p < 0.05) while tibia was structurally and radiological intact for 20 weeks post-irradiation. Hypocellularity, hypoxia and oxidative stress were higher in irradiated mandible (p < 0.001) than tibia (p < 0.01) but vascular damage was similar at both skeletal sites. Combined effects of radiation and minor trauma promoted mandibular alveolar bone loss and tibial fracture
ORN has a more rapid onset in mandible relative to tibia in the rat
This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Osteoradionecrosis, Hypovascular, Hypocellular, Radiotherapy, Oxidative stress, Animal model
Damek-Poprawa, M., Booth, S., Wright, A. C., Maity, A., & Akintoye, S. O. (2013). Onset of Mandible and Tibia Osteoradionecrosis – a Comparative Pilot Study in the rat. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 115 (2), 201-211. http://dx.doi.org/10.1016/j.oooo.2012.09.008
Date Posted: 10 August 2018
This document has been peer reviewed.