Departmental Papers (Dental)

Document Type

Journal Article

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Publication Source

International Journal of Oral Science



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Diabetes mellitus and periodontal disease are chronic diseases affecting a large number of populations worldwide. Changed bone metabolism is one of the important long-term complications associated with diabetes mellitus. Alveolar bone loss is one of the main outcomes of periodontitis, and diabetes is among the primary risk factors for periodontal disease. In this review, we summarise the adverse effects of diabetes on the periodontium in periodontitis subjects, focusing on alveolar bone loss. Bone remodelling begins with osteoclasts resorbing bone, followed by new bone formation by osteoblasts in the resorption lacunae. Therefore, we discuss the potential mechanism of diabetes-enhanced bone loss in relation to osteoblasts and osteoclasts.

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bone loss, diabetes mellitus, hyperglycemia, inflammation, osseous, osteoblast, osteoclast, periodontitis

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Dentistry Commons



Date Posted: 10 August 2018

This document has been peer reviewed.