Departmental Papers (Dental)

Document Type

Journal Article

Date of this Version

2015

Publication Source

International Journal of Oral Science

Volume

7

Start Page

63

Last Page

72

DOI

10.1038/ijos.2015.2

Abstract

Diabetes mellitus and periodontal disease are chronic diseases affecting a large number of populations worldwide. Changed bone metabolism is one of the important long-term complications associated with diabetes mellitus. Alveolar bone loss is one of the main outcomes of periodontitis, and diabetes is among the primary risk factors for periodontal disease. In this review, we summarise the adverse effects of diabetes on the periodontium in periodontitis subjects, focusing on alveolar bone loss. Bone remodelling begins with osteoclasts resorbing bone, followed by new bone formation by osteoblasts in the resorption lacunae. Therefore, we discuss the potential mechanism of diabetes-enhanced bone loss in relation to osteoblasts and osteoclasts.

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This work is licensed under a Creative Commons Attribution- NonCommercial-ShareAlike 3.0 Unported License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0.

Keywords

bone loss, diabetes mellitus, hyperglycemia, inflammation, osseous, osteoblast, osteoclast, periodontitis

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Date Posted:30 July 2018

This document has been peer reviewed.