Departmental Papers (Dental)

Document Type

Journal Article

Date of this Version

2019

Publication Source

BioMed Research International

Volume

2019

Start Page

Article number 4934128

DOI

10.1155/2019/4934128

Abstract

Introduction. With an increasing demand for orthodontic treatment for adult patients, orthodontic professionals are constantly seeking novel strategies and technologies that can accelerate tooth movement in order to shorten the treatment period. For instance, in recent years, the influences of different surgical techniques on orthodontic tooth movement in the ipsilateral side of surgery were intensively investigated. Here, we attempt to examine if corticotomy could also affect the rate of tooth movement in the contralateral side of the surgery by using a rodent model. Materials and Methods. 72 eight-week-old Sprague-Dawley rats were randomly divided into three groups as follows: The Control group (orthodontic treatment devices delivered only, no tooth movement), the orthodontic tooth movement (OTM) group (orthodontic treatment devices delivered and orthodontic treatment performed), and the Corticotomy + OTM group (remote corticotomy performed, orthodontic treatment devices delivered, followed by orthodontic treatment). The surgical procedure was conducted on the right side of the maxilla at the time of appliance placement and a force of 60 g was applied between the maxillary left first molar and maxillary incisors using nickel-titanium springs to stimulate OTM. The OTM distance and speed were tracked at 3, 7, 14, and 28 days post-surgery, followed by histological and immunohistochemical assessments. Results. In comparison with orthodontic treatment only, the contralateral corticotomy significantly accelerated OTM. Furthermore, animals undergoing corticotomy + OTM presented with a greater number of osteoclasts on the compression side, stronger staining of the osteogenic marker on the tension side, and higher expression of an inflammatory marker than the OTM group animals. Conclusion. Our current study demonstrates that remote corticotomy effectively accelerates alveolar bone remodeling and OTM. The study enriches our understanding of the regional acceleratory phenomenon (RAP) and offers an alternative strategy for accelerating OTM to shorten the orthodontic treatment period. © 2019 Min Zou et al.

Comments

At the time of publication, author Chenshuang Li was affiliated with the College of Stomatology, Xi'An Jiaotong University and the School of Dentistry, University of California. Currently, (s)he is a faculty member at the School of Medical Dentistry at the University of Pennsylvania.

Keywords

Animals, Bone Remodeling, Bone Resorption, Disease Models, Animal, Humans, Incisor, Maxilla, Molar, Nickel, Orthodontic Wires, Osteoclasts, Osteogenesis, Rats, Titanium, Tooth Movement Techniques, interleukin 6, osteocalcin, nickel, titanium, titanium nickelide, adult, alveolar bone, animal experiment, animal model, Article, bone remodeling, controlled study, corticotomy, female, first molar, immune response, incisor, maxillary first molar, maxillary third molar, nonhuman, orthodontic procedure, orthodontic tooth movement, osteoclast, periodontal disease, protein expression, rat, animal, bone development, disease model, drug effect, growth, development and aging, human, maxilla, metabolism, molar tooth, orthodontic tooth movement, orthodontic wire, osteolysis, pathology, surgery

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Date Posted: 10 February 2023

This document has been peer reviewed.