Date of this Version
Current Osteoporosis Reports
Diabetes mellitus is a metabolic disorder that increases fracture risk, interferes with bone formation, and impairs fracture healing. Type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) both increase fracture risk and have several common features that affect the bone including hyperglycemia and increased advanced glycation end product (AGE) formation, reactive oxygen species (ROS) generation, and inflammation. These factors affect both osteoblasts and osteoclasts leading to increased osteoclasts and reduced numbers of osteoblasts and bone formation. In addition to fracture healing, T1DM and T2DM impair bone formation under conditions of perturbation such as bacteria-induced periodontal bone loss by increasing osteoblast apoptosis and reducing expression of factors that stimulate osteoblasts such as BMPs and growth factors.
The final publication is available at Springer via http://dx.doi.org/10.1007/s11914-015-0286-8.
diabetes, inflammation, advanced glycation end-products (age), oxidative stress, insulin, hyperglycemia, osteoblast, osteoclast, fracture healing
Jiao, H., Xiao, E., & Graves, D. T. (2015). Diabetes and its Effect on Bone and Fracture Healing. Current Osteoporosis Reports, 13 (5), 327-335. http://dx.doi.org/10.1007/s11914-015-0286-8
Date Posted: 10 August 2018
This document has been peer reviewed.