Departmental Papers (Dental)

Document Type

Journal Article

Date of this Version

10-2015

Publication Source

Current Osteoporosis Reports

Volume

13

Issue

5

Start Page

327

Last Page

335

DOI

10.1007/s11914-015-0286-8

Abstract

Diabetes mellitus is a metabolic disorder that increases fracture risk, interferes with bone formation, and impairs fracture healing. Type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) both increase fracture risk and have several common features that affect the bone including hyperglycemia and increased advanced glycation end product (AGE) formation, reactive oxygen species (ROS) generation, and inflammation. These factors affect both osteoblasts and osteoclasts leading to increased osteoclasts and reduced numbers of osteoblasts and bone formation. In addition to fracture healing, T1DM and T2DM impair bone formation under conditions of perturbation such as bacteria-induced periodontal bone loss by increasing osteoblast apoptosis and reducing expression of factors that stimulate osteoblasts such as BMPs and growth factors.

Copyright/Permission Statement

The final publication is available at Springer via http://dx.doi.org/10.1007/s11914-015-0286-8.

Keywords

diabetes, inflammation, advanced glycation end-products (age), oxidative stress, insulin, hyperglycemia, osteoblast, osteoclast, fracture healing

Included in

Dentistry Commons

Share

COinS
 

Date Posted:30 July 2018

This document has been peer reviewed.