Departmental Papers (Dental)
Document Type
Review
Date of this Version
9-2019
Publication Source
Brain Research Bulletin
Volume
151
Start Page
92
Last Page
108
DOI
10.1016/j.brainresbull.2018.10.016
Abstract
Retinal injuries and diseases are major causes of human disability involving vision impairment by the progressive and permanent loss of retinal neurons. During development, assembly of this tissue entails a successive and overlapping, signal-regulated engagement of complex events that include proliferation of progenitors, neurogenesis, cell death, neurochemical differentiation and synaptogenesis. During retinal damage, several of these events are re-activated with both protective and detrimental consequences. Purines and pyrimidines, along with their metabolites are emerging as important molecules regulating both retinal development and the tissue's responses to damage. The present review provides an overview of the purinergic signaling in the developing and injured retina. Recent findings on the presence of vesicular and channel-mediated ATP release by retinal and retinal pigment epithelial cells, adenosine synthesis and release, expression of receptors and intracellular signaling pathways activated by purinergic signaling in retinal cells are reported. The pathways by which purinergic receptors modulate retinal cell proliferation, migration and death of retinal cells during development and injury are summarized. The contribution of nucleotides to the self-repair of the injured zebrafish retina is also discussed. © 2018 Elsevier Inc.
Keywords
ATP, Adenosine, Nucleotides, P1 receptors, P2 receptors, Retina diseases, Adenosine, Adenosine Triphosphate, Animals, Cell Death, Cell Differentiation, Humans, Purines, Receptors, Purinergic, Receptors, Purinergic P2X, Receptors, Purinergic P2Y, Retina, Signal Transduction, adenosine, adenosine receptor, adenosine triphosphate, cytokine, glutamic acid, growth factor, purine derivative, purinergic P2X receptor, purinergic P2Y receptor, purinergic receptor, adenosine, adenosine triphosphate, purine, purine derivative, purinergic P2X receptor, purinergic P2Y receptor, purinergic receptor, cell death, cell migration, cell proliferation, cell survival, diabetic retinopathy, excitotoxicity, glaucoma, glia, human, intracellular signaling, nonhuman, optic nerve injury, priority journal, retina cell, retina development, retina disease, retina ischemia, retinal pigment epithelium, Review, signal transduction, tissue regeneration, zebra fish, animal, cell differentiation, metabolism, pathology, physiology, retina, signal transduction.
Recommended Citation
Ventura, A. L., dos Santos-Rodrigues, A., Mitchell, C. H., & Faillace, M. P. (2019). Purinergic Signaling in the Retina: From Development to Disease. Brain Research Bulletin, 151 92-108. http://dx.doi.org/10.1016/j.brainresbull.2018.10.016
Date Posted:30 June 2022
This document has been peer reviewed.
Comments
Brain Research Bulletin not open access. Uploaded pdf from PubMed Central.
PMCID: PMC6525091