Departmental Papers (Dental)
Document Type
Journal Article
Date of this Version
2016
Publication Source
Journal of Diabetes and its Complications
Volume
30
Issue
8
Start Page
1593
Last Page
1599
DOI
10.1016/j.jdiacomp.2016.07.011
Abstract
Background
The effect of the interaction between type 2 diabetes and dyslipidemia on inflammation and lipid peroxidation (LPO) has not been assessed.
Aim
To investigate whether diabetes coupled with dyslipidemia alters oxidative metabolism leading to increased LPO products and inflammatory status.
Methods
100 patients were divided into four groups based upon diabetic and dyslipidemic status: poorly controlled diabetes with dyslipidemia (DM-PC/D), well-controlled diabetes with dyslipidemia (DM-WC/D), normoglycemic individuals with dyslipidemia (NG/D), and normoglycemic individuals without dyslipidemia (NG/ND). Plasma was evaluated for an LPO product (MDA), antioxidant levels and inflammatory cytokines.
Results
Diabetics presented significantly higher levels of LPO (p < 0.05) and the DM-PC/D had higher levels of proinflammatory cytokines and MDA in the plasma in comparison with normoglycemics (p < 0.05). Interestingly IL1-β, IL-6, and TNF-α in DM-WC/D were not statistically different from those in DM-PC/D. Normoglycemic individuals with dyslipidemia presented significantly increased levels of IL-6 and TNF-α when compared to normoglycemic without dyslipidemia (p < 0.05). MDA levels were also positively correlated with the presence of DM complications (r = 0.42, p < 0.01).
Conclusions
These findings show that dyslipidemia is associated with an increased inflammatory status, even in well-controlled diabetics and in normoglycemics. Our results suggest that lipid metabolism and peroxidation are important for the development of inflammation, which is elevated in several complications associated with diabetes.
Copyright/Permission Statement
© . This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/.
Keywords
lipid peroxidation, diabetes mellitus type 2, cytokines, dyslipidemia, inflammation
Recommended Citation
de Souza Bastos, A., Graves, D. T., de Melo Louireiro, A. P., Rossa, C., Cruz Tfaile Corbi, S., Frizzera, F., Mantuaneli Scarel-Caminaga, R., Olsen-Camara, N., Andriankaja, O. M., Hiyane, M. I., & Perez Orrico, S. R. (2016). Diabetes and Increased Lipid Peroxidation are Associated with Systemic Inflammation Even in Well-Controlled Patients. Journal of Diabetes and its Complications, 30 (8), 1593-1599. http://dx.doi.org/10.1016/j.jdiacomp.2016.07.011
Date Posted: 10 August 2018
This document has been peer reviewed.