Departmental Papers (Dental)

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Oral Diseases





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As the emphasis shifts from damage mitigation to disease prevention or reversal of early disease in the oral cavity, the need for sensitive and accurate detection and diagnostic tools become more important. Many novel and emergent optical diagnostic modalities for the oral cavity are becoming available to clinicians with a variety of desirable attributes including: (i) non-invasiveness, (ii) absence of ionizing radiation, (iii) patient-friendliness, (iv) real-time information (v) repeatability, and (vi) high-resolution surface and subsurface images. In this article, the principles behind optical diagnostic approaches, their feasibility and applicability for imaging soft and hard tissues, and their potential usefulness as a tool in the diagnosis of oral mucosal lesions, dental pathologies, and other dental applications will be reviewed. The clinical applications of light-based imaging technologies in the oral cavity and of their derivative devices will be discussed to provide the reader with a comprehensive understanding of emergent diagnostic modalities. © 2010 John Wiley & Sons A/S.


At the time of publication, author A. Le was affiliated with the University of Southern California School of Dentistry. Currently, (s)he is a faculty member at the School of Dental Medicine at the University of Pennsylvania.


Author keywords: Dental, Diagnosis, Optical, Oral MeSH: Diagnostic Imaging, Fluorescence, Humans, Lasers, Light, Mouth Diseases, Optical Devices, Spectrum Analysis, Tomography, Optical Coherence, Tooth Diseases, Transillumination EMTREE drug terms: aminolevulinic acid, aminolevulinic acid hexyl ester, aminolevulinic acid methyl ester, metvixr, photofrin, photosensitizing agent, tetrakis(3 hydroxyphenyl)chlorin, unclassified drug EMTREE medical terms: chemoluminescence, clinical feature, confocal microscopy, dental caries, diagnostic accuracy, fluorescence imaging, human, in vivo study, laser fluorescence, magnifying endoscopy, mouth cancer, mouth cavity, mouth lesion, mucosa inflammation, multiphoton microscopy, nonhuman, optical coherence tomography, oropharynxl mucositis, periodontal disease, polarization microscopy, priority journal, review, sensitivity and specificity



Date Posted: 10 February 2023

This document has been peer reviewed.