Departmental Papers (Dental)
Date of this Version
A plethora of both acute and chronic conditions, including traumatic, degenerative, malignant, or congenital disorders, commonly induce bone disorders often associated with severe persisting pain and limited mobility. Over 1 million surgical procedures involving bone excision, bone grafting, and fracture repair are performed each year in the U.S. alone, resulting in immense levels of public health challenges and corresponding financial burdens. Unfortunately, the innate self-healing capacity of bone is often inadequate for larger defects over a critical size. Moreover, as direct transplantation of committed osteoblasts is hindered by deficient cell availability, limited cell spreading, and poor survivability, an urgent need for novel cell sources for bone regeneration is concurrent. Thanks to the development in stem cell biology and cell reprogramming technology, many multipotent and pluripotent cells that manifest promising osteogenic potential are considered the regenerative remedy for bone defects. Considering these cells' investigation is still in its relative infancy, each of them offers their own particular challenges that must be conquered before the large-scale clinical application. © 2021 The Authors. MedComm published by Sichuan International Medical Exchange & Promotion Association (SCIMEA) and John Wiley & Sons Australia, Ltd.
bone regeneration, multipotent stem cells, pluripotent stem cells
Li, C., Mills, Z., & Zheng, Z. (2021). Novel Cell Sources for Bone Regeneration. MedComm, 2 (2), 145-174. http://dx.doi.org/10.1002/mco2.51
Endodontics and Endodontology Commons, Oral Biology and Oral Pathology Commons, Other Dentistry Commons, Periodontics and Periodontology Commons
Date Posted: 10 February 2023
This document has been peer reviewed.