Departmental Papers (Dental)
Document Type
Journal Article
Date of this Version
10-2012
Publication Source
Oral Diseases
Volume
18
Issue
7
Start Page
625
Last Page
632
DOI
10.1111/j.1601-0825.2012.01911.x
Abstract
Non-exposed bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a newly reported complication arising from bisphosphonate therapy that presents with atypical symptoms and no apparent mucosal fenestration or exposure of necrotic bone. The clinical observation of the presence of necrotic bone underneath normal epithelial coverage was not conclusive for the diagnosis of BRONJ based on current guidelines established by the American Association of Oral and Maxillofacial Surgeons (AAOMS) and the American Society for Bone and Mineral Research (ASBMR), which specify the presence of clinically exposed necrotic bone for more than 8weeks. Hence, the purpose of this review is to critically assess the current guidelines for diagnosis and management of BRONJ and propose a modified staging system and treatment guidelines to properly address the non-exposed variant of BRONJ lesions. © 2012 John Wiley & Sons A/S.
Keywords
Author keywords: Craniofacial, Diagnostics, Medicine, Oncology MeSH: Angiogenesis Inhibitors, Anti-Bacterial Agents, Antibodies, Monoclonal, Humanized, Bisphosphonate-Associated Osteonecrosis of the Jaw, Humans, Jaw Diseases, Osteonecrosis, Practice Guidelines as Topic, Terminology as Topic EMTREE drug terms: antibiotic agent, bisphosphonic acid derivative EMTREE medical terms: adverse drug reaction, antibiotic therapy, article, disease course, human, jaw osteonecrosis, medical assessment, nonexposed bisphosphonate related jaw osteonecrosis, practice guideline, priority journal, staging
Recommended Citation
Patel, S., Choyee, S., Uyanne, J., Nguyen, A. L., Lee, P., Sedghizadeh, P. P., Kumar, S. K., Lytle, J., Shi, S., & Le, A. D. (2012). Non-exposed Bisphosphonate-related Osteonecrosis of the Jaw: A Critical Assessment of Current Definition, Staging, and Treatment Guidelines. Oral Diseases, 18 (7), 625-632. http://dx.doi.org/10.1111/j.1601-0825.2012.01911.x
Included in
Oral and Maxillofacial Surgery Commons, Oral Biology and Oral Pathology Commons, Periodontics and Periodontology Commons
Date Posted: 10 February 2023
This document has been peer reviewed.
Comments
At the time of publication, author Songtao Shi was affiliated with Herman Ostrow School of Dentistry of University of Southern California. Currently, (s)he is a faculty member at the School of Dental Medicine at the University of Pennsylvania.
At the time of publication, author Anh D. Le was affiliated with Herman Ostrow School of Dentistry of University of Southern California and LAC+USC Medical Center. Currently, (s)he is a faculty member at the School of Dental Medicine at the University of Pennsylvania.