Departmental Papers (Dental)

Document Type

Journal Article

Date of this Version

10-2012

Publication Source

Oral Diseases

Volume

18

Issue

7

Start Page

625

Last Page

632

DOI

10.1111/j.1601-0825.2012.01911.x

Abstract

Non-exposed bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a newly reported complication arising from bisphosphonate therapy that presents with atypical symptoms and no apparent mucosal fenestration or exposure of necrotic bone. The clinical observation of the presence of necrotic bone underneath normal epithelial coverage was not conclusive for the diagnosis of BRONJ based on current guidelines established by the American Association of Oral and Maxillofacial Surgeons (AAOMS) and the American Society for Bone and Mineral Research (ASBMR), which specify the presence of clinically exposed necrotic bone for more than 8weeks. Hence, the purpose of this review is to critically assess the current guidelines for diagnosis and management of BRONJ and propose a modified staging system and treatment guidelines to properly address the non-exposed variant of BRONJ lesions. © 2012 John Wiley & Sons A/S.

Comments

At the time of publication, author Songtao Shi was affiliated with Herman Ostrow School of Dentistry of University of Southern California. Currently, (s)he is a faculty member at the School of Dental Medicine at the University of Pennsylvania.

At the time of publication, author Anh D. Le was affiliated with Herman Ostrow School of Dentistry of University of Southern California and LAC+USC Medical Center. Currently, (s)he is a faculty member at the School of Dental Medicine at the University of Pennsylvania.

Keywords

Author keywords: Craniofacial, Diagnostics, Medicine, Oncology MeSH: Angiogenesis Inhibitors, Anti-Bacterial Agents, Antibodies, Monoclonal, Humanized, Bisphosphonate-Associated Osteonecrosis of the Jaw, Humans, Jaw Diseases, Osteonecrosis, Practice Guidelines as Topic, Terminology as Topic EMTREE drug terms: antibiotic agent, bisphosphonic acid derivative EMTREE medical terms: adverse drug reaction, antibiotic therapy, article, disease course, human, jaw osteonecrosis, medical assessment, nonexposed bisphosphonate related jaw osteonecrosis, practice guideline, priority journal, staging

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Date Posted: 10 February 2023

This document has been peer reviewed.