Departmental Papers (Dental)
Date of this Version
Head and Neck Pathology
In this article we outline the molecular findings of select odontogenic tumors. In each section, we briefly review selected the clinicoradiographic, histologic, immunologic features, focusing on the molecular findings and their applications in practice. The understanding of molecular pathobiology at various other organ sites has developed quite rapidly in recent years, however much remains unknown about the genetic profile of odontogenic tumors. Improved understanding of mutations in odontogenic tumors may clarify classification schema and elucidate targets for novel therapies. Molecular testing will no doubt improve our understanding of odontogenic tumor pathogenesis and will likely be, someday, an important component of routine clinical practice and its role will only increase in the coming years.
Odontogenic tumors, Molecular pathology, Translocation, Mutation, EWSR1, BRAF, PTCH
Bilodeau, E. A., Prasad, J. L., Alawi, F., & Seethala, R. R. (2014). Molecular and Genetic Aspects of Odontogenic Lesions. Head and Neck Pathology, 8 (4), 400-410. http://dx.doi.org/10.1007/s12105-014-0588-7
Date Posted: 10 February 2023
This document has been peer reviewed.