Molecular and Genetic Aspects of Odontogenic Lesions

Loading...
Thumbnail Image
Penn collection
Departmental Papers (Dental)
Degree type
Discipline
Subject
Odontogenic tumors
Molecular pathology
Translocation
Mutation
EWSR1
BRAF
PTCH
Dentistry
Funder
Grant number
License
Copyright date
Distributor
Related resources
Author
Bilodeau, Elizabeth A.
Prasad, Joanne L.
Alawi, Faizan
Seethala, Raja R.
Contributor
Abstract

In this article we outline the molecular findings of select odontogenic tumors. In each section, we briefly review selected the clinicoradiographic, histologic, immunologic features, focusing on the molecular findings and their applications in practice. The understanding of molecular pathobiology at various other organ sites has developed quite rapidly in recent years, however much remains unknown about the genetic profile of odontogenic tumors. Improved understanding of mutations in odontogenic tumors may clarify classification schema and elucidate targets for novel therapies. Molecular testing will no doubt improve our understanding of odontogenic tumor pathogenesis and will likely be, someday, an important component of routine clinical practice and its role will only increase in the coming years.

Advisor
Date Range for Data Collection (Start Date)
Date Range for Data Collection (End Date)
Digital Object Identifier
Series name and number
Publication date
2014-01-01
Journal title
Head and Neck Pathology
Volume number
Issue number
Publisher
Publisher DOI
Journal Issue
Comments
Recommended citation
Collection