Departmental Papers (Dental)
Identification of Novel Targets of Knee Osteoarthritis Shared by Cartilage and Synovial Tissue
Date of this Version
International Journal of Molecular Sciences
Arthritis is the leading cause of disability among adults, while osteoarthritis (OA) is the most common form of arthritis that results in cartilage loss. However, accumulating evidence suggests that the protective hyaline cartilage should not be the sole focus of OA treatment. Particularly, synovium also plays essential roles in OA’s initiation and progression and warrants serious consideration when battling against OA. Thus, biomarkers with similar OA-responsive expressions in cartilage and synovium should be the potential targets for OA treatment. On the other hand, molecules with a distinguished response during OA in cartilage and synovium should be ruled out as OA therapeutic(s) to avoid controversial effects in different tissues. Here, to pave the path for developing a new generation of OA therapeutics, two published transcriptome datasets of knee articular cartilage and synovium were analyzed in-depth. Genes with statistically significantly different expression in OA and healthy cartilage were compared with those in the synovium. Thirty-five genes with similar OA-responsive expression in both tissues were identified while recognizing three genes with opposite OA-responsive alteration trends in cartilage and synovium. These genes were clustered based on the currently available knowledge, and the potential impacts of these clusters in OA were explored. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
Biomarker, Cartilage, Osteoarthritis, Synovium, Whole transcriptome sequencing, Biomarkers, Cartilage, Articular, Databases, Genetic, Female, Gene Expression Profiling, Humans, Male, Molecular Targeted Therapy, Osteoarthritis, Knee, Protein Interaction Maps, Sequence Analysis, RNA, Synovial Membrane, apolipoprotein, chitinase 3 like protein 1, collagenase 3, complement component C1q, cyclin dependent kinase, epsilon interferon, formylpeptide receptor, mitogen activated protein kinase kinase, myocilin, phosphatidylinositol 3 kinase, prolyl endopeptidase, reactive oxygen metabolite, tumor necrosis factor, biological marker, amino acid sequence, angiogenesis, Article, cartilage, cell migration, clinical article, controlled study, female, gene expression, human, immunoglobulin domain, knee osteoarthritis, lymphokine activated killer cell, male, microcephaly, normal human, protein protein interaction, RNA sequence, synovium, articular cartilage, gene expression profiling, genetic database, genetics, knee osteoarthritis, molecularly targeted therapy, pathology, physiology, protein analysis, sequence analysis, synovium
Li, C., & Zheng, Z. (2020). Identification of Novel Targets of Knee Osteoarthritis Shared by Cartilage and Synovial Tissue. International Journal of Molecular Sciences, 21 (17), 1-19. http://dx.doi.org/10.3390/ijms21176033
Date Posted: 10 February 2023