Identification of Novel Targets of Knee Osteoarthritis Shared by Cartilage and Synovial Tissue

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Departmental Papers (Dental)
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Biomarker
Cartilage
Osteoarthritis
Synovium
Whole transcriptome sequencing
Biomarkers
Cartilage
Articular
Databases
Genetic
Female
Gene Expression Profiling
Humans
Male
Molecular Targeted Therapy
Osteoarthritis
Knee
Protein Interaction Maps
Sequence Analysis
RNA
Synovial Membrane
apolipoprotein
chitinase 3 like protein 1
collagenase 3
complement component C1q
cyclin dependent kinase
epsilon interferon
formylpeptide receptor
mitogen activated protein kinase kinase
myocilin
phosphatidylinositol 3 kinase
prolyl endopeptidase
reactive oxygen metabolite
tumor necrosis factor
biological marker
amino acid sequence
angiogenesis
Article
cartilage
cell migration
clinical article
controlled study
female
gene expression
human
immunoglobulin domain
knee osteoarthritis
lymphokine activated killer cell
male
microcephaly
normal human
protein protein interaction
RNA sequence
synovium
articular cartilage
gene expression profiling
genetic database
genetics
knee osteoarthritis
molecularly targeted therapy
pathology
physiology
protein analysis
sequence analysis
synovium
Dentistry
Orthodontics and Orthodontology
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Li, Chenshuang
Zheng, Zhong
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Abstract

Arthritis is the leading cause of disability among adults, while osteoarthritis (OA) is the most common form of arthritis that results in cartilage loss. However, accumulating evidence suggests that the protective hyaline cartilage should not be the sole focus of OA treatment. Particularly, synovium also plays essential roles in OA’s initiation and progression and warrants serious consideration when battling against OA. Thus, biomarkers with similar OA-responsive expressions in cartilage and synovium should be the potential targets for OA treatment. On the other hand, molecules with a distinguished response during OA in cartilage and synovium should be ruled out as OA therapeutic(s) to avoid controversial effects in different tissues. Here, to pave the path for developing a new generation of OA therapeutics, two published transcriptome datasets of knee articular cartilage and synovium were analyzed in-depth. Genes with statistically significantly different expression in OA and healthy cartilage were compared with those in the synovium. Thirty-five genes with similar OA-responsive expression in both tissues were identified while recognizing three genes with opposite OA-responsive alteration trends in cartilage and synovium. These genes were clustered based on the currently available knowledge, and the potential impacts of these clusters in OA were explored. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.

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2020-09-01
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International Journal of Molecular Sciences
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