Departmental Papers (Dental)

Document Type

Journal Article

Date of this Version

11-2012

Publication Source

Journal of Dental Research

Volume

91

Issue

11

Start Page

1011

Last Page

1018

DOI

10.1177/0022034512461016

Abstract

Mesenchymal stem cells (MSCs) represent a heterogeneous population of progenitor cells with self-renewal and multipotent differentiation potential. Aside from their regenerative role, extensive in vitro and in vivo studies have demonstrated that MSCs are capable of potent immunomodulatory effects on a variety of innate and adaptive immune cells. In this article, we will review recent experimental studies on the characterization of a unique population of MSCs derived from human oral mucosa and gingiva, especially their immunomodulatory and anti-inflammatory functions and their application in the treatment of several in vivo models of inflammatory diseases. The ease of isolation, accessible tissue source, and rapid ex vivo expansion, with maintenance of stable stem-cell-like phenotypes, render oral mucosa- and gingiva-derived MSCs a promising alternative cell source for MSC-based therapies. © 2012 International & American Associations for Dental Research.

Keywords

Author keywords: gingival-derived mesenchymal stem cells, immunomodulation, inflammatory disease, multipotency, oral mucosa, regeneration MeSH: Animals, Dendritic Cells, Fibroblasts, Gingiva, Humans, Immunomodulation, Inflammation, Lymphocytes, Macrophages, Mast Cells, Mesenchymal Stromal Cells, Mouth Mucosa, Receptor Cross-Talk, Regeneration EMTREE medical terms: animal, article, cytology, dendritic cell, fibroblast, gingiva, human, immunomodulation, inflammation, lymphocyte, macrophage, mast cell, mesenchymal stroma cell, mouth mucosa, physiology, regeneration, signal transduction

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Date Posted: 10 February 2023

This document has been peer reviewed.