Departmental Papers (Dental)

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Journal Article

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Publication Source

Journal of Cellular and Molecular Medicine





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Hypertrophic scarring is a major postoperative complication which leads to severe disfigurement and dysfunction in patients and usually requires multiple surgical revisions due to its high recurrence rates. Excessive-mechanical-loading across wounds is an important initiator of hypertrophic scarring formation. In this study, we demonstrate that intradermal administration of a single extracellular matrix (ECM) molecule—fibromodulin (FMOD) protein—can significantly reduce scar size, increase tensile strength, and improve dermal collagen architecture organization in the normal and even excessive-mechanical-loading red Duroc pig wound models. Since pig skin is recognized by the Food and Drug Administration as the closest animal equivalent to human skin, and because red Duroc pigs show scarring that closely resembles human proliferative scarring and hypertrophic scarring, FMOD-based technologies hold high translational potential and applicability to human patients suffering from scarring—especially hypertrophic scarring. © 2018 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.


At the time of publication, author Chenshuang Li was affiliated with the School of Dentistry, University of California. Currently, (s)he is a faculty member at the School of Dental Medicine at the University of Pennsylvania.


fibromodulin, hypertrophic scarring, scarring, tissue regeneration, wound healing, Animals, Cicatrix, Extracellular Matrix Proteins, Fibromodulin, Humans, Injections, Intradermal, Skin, Skin Diseases, Stress, Mechanical, Swine, Tensile Strength, Wound Healing, collagen, fibromodulin, fibromodulin, scleroprotein, animal cell, animal model, animal tissue, Article, confocal laser scanning microscopy, controlled study, cytoarchitecture, histology, mechanical stress, musculoskeletal system parameters, nonhuman, pig, priority journal, scar formation, scar size, scar tensile strength, skin injury, visual analog scale, wound assessment, animal, drug effect, genetics, human, injury, intradermal drug administration, pathology, scar, skin, skin disease, tensile strength, wound healing



Date Posted: 10 February 2023

This document has been peer reviewed.