Dental Stem Cells: Sources and Potential Applications
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DPSCs Dental Pulp Stem Cells
DSCs Dental Stem Cells
GMSCs Gingiva-Derived Mesenchymal Stem/Stromal Cells
Immunomodulation
Inflammatory Disease
MSCs Mesenchymal Stem Cells
Multipotency
PDLSCs Periodontal Ligament Stem Cells
SCAP Stem Cells From Root Apical Papilla
SHED Stem Cells From Human Exfoliated Deciduous Teeth
Dentistry
Endodontics and Endodontology
Oral and Maxillofacial Surgery
Oral Biology and Oral Pathology
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Abstract
In recent years, stem cell research in dentistry has grown rapidly with the potential application for oral and maxillofacial tissue regeneration. Mesenchymal stem cells (MSCs) from the oral and maxillofacial region are easy to access, have a high proliferation rate, multipotency, and potent immunomodulatory functions. They are excellent cell sources not only for stem cell-based therapy of dental and craniofacial diseases, but also with the potential for the treatment of other inflammatory diseases. In this review, we provide an overview of different types of MSCs that have been isolated and characterized from several origins such as dental pulp, exfoliated deciduous teeth, the periodontal ligament, the dental follicle, the dental papilla, oral mucosa, and gingiva, with the focus on the potential clinical applications for each type of dental stem cell. © 2014, Springer International Publishing AG.