Departmental Papers (Dental)

Document Type

Journal Article

Date of this Version

1-2-2021

Publication Source

International Journal of Molecular Sciences

Volume

22

Issue

2

Start Page

Article number 569

DOI

10.3390/ijms22020569

Abstract

As the leading cause of disability, osteoarthritis (OA) affects people of all ages, sexes, and races. With the increasing understanding of OA, the sex differences have attracted specific attention as the burden of OA is greater in women. There is no doubt that gender-specific OA management has great potential for precision treatment. On the other hand, from the marketing aspect, a medication targeting the OA-responsive biomarker(s) shared by both genders is more favorable for drug development. Thus, in the current study, a published transcriptome dataset of knee articular cartilage was used to compare OA and healthy samples for identifying the genes with the same significantly different expression trend in both males and females. With 128 genes upregulated and 143 genes downregulated in both OA males and females, 9 KEGG pathways have been enriched based on the current knowledge, including ‘renal cell carcinoma,’ ‘ECM-receptor interaction,’ ‘HIF-1 signaling pathway,’ ‘MicroRNAs in cancer,’ ‘focal adhesion,’ ‘Relaxin signaling pathway,’ ‘breast cancer,’ ‘PI3K-Akt signaling pathway,’ and ‘human papillomavirus infection.’ Here, we explore the potential impacts of these clusters in OA. We also analyze the identified ‘cell plasma membrane related genes’ in-depth to identify the potential chondrocyte cell surface target(s) of OA management. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

Biomarker, Cartilage, Gender, Osteoarthritis, Whole transcriptome sequencing, Adult, Aged, Aged, 80 and over, Biomarkers, Cartilage, Chondrocytes, Female, Gene Expression Regulation, Humans, Knee Joint, Male, MicroRNAs, Middle Aged, Osteoarthritis, Knee, Sex Characteristics, Signal Transduction, Transcriptome, beta integrin, cadherin, cadherin 2, caspase recruitment domain protein 15, CD18 antigen, glutamine receptor 2, growth factor receptor, hepsin, integrin beta 8, mast/stem cell growth factor receptor kit, microRNA, microsomal aminopeptidase, n methyl dextro aspartic acid receptor 2A, nerve cell adhesion molecule, neural cell adhesion molecule 1, platelet derived growth factor C, receptor activity modifying protein 3, relaxin, retinoic acid receptor alpha, secreted frizzled related protein 4, tenascin, tenascin r, Thy 1 membrane glycoprotein, transcriptome, unclassified drug, vasculotropin A, Wnt5a protein, biological marker, microRNA, transcriptome, Article, articular cartilage, breast cancer, controlled study, down regulation, female, focal adhesion, gene expression, human, knee meniscus, knee osteoarthritis, male, multidimensional scaling, papillomavirus infection, Pi3K/Akt signaling, principal component analysis, protein protein interaction, renal cell carcinoma, RNA sequencing, upregulation, adult, aged, blood, cartilage, chondrocyte, gene expression regulation, genetics, growth, development and aging, knee, knee osteoarthritis, metabolism, middle aged, pathology, sexual characteristics, signal transduction, very elderly

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Date Posted: 10 February 2023