Cartilage Targets of Knee Osteoarthritis Shared by Both Genders

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Departmental Papers (Dental)
Degree type
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Biomarker
Cartilage
Gender
Osteoarthritis
Whole transcriptome sequencing
Adult
Aged
Aged
80 and over
Biomarkers
Cartilage
Chondrocytes
Female
Gene Expression Regulation
Humans
Knee Joint
Male
MicroRNAs
Middle Aged
Osteoarthritis
Knee
Sex Characteristics
Signal Transduction
Transcriptome
beta integrin
cadherin
cadherin 2
caspase recruitment domain protein 15
CD18 antigen
glutamine receptor 2
growth factor receptor
hepsin
integrin beta 8
mast/stem cell growth factor receptor kit
microRNA
microsomal aminopeptidase
n methyl dextro aspartic acid receptor 2A
nerve cell adhesion molecule
neural cell adhesion molecule 1
platelet derived growth factor C
receptor activity modifying protein 3
relaxin
retinoic acid receptor alpha
secreted frizzled related protein 4
tenascin
tenascin r
Thy 1 membrane glycoprotein
transcriptome
unclassified drug
vasculotropin A
Wnt5a protein
biological marker
microRNA
transcriptome
Article
articular cartilage
breast cancer
controlled study
down regulation
female
focal adhesion
gene expression
human
knee meniscus
knee osteoarthritis
male
multidimensional scaling
papillomavirus infection
Pi3K/Akt signaling
principal component analysis
protein protein interaction
renal cell carcinoma
RNA sequencing
upregulation
adult
aged
blood
cartilage
chondrocyte
gene expression regulation
genetics
growth
development and aging
knee
knee osteoarthritis
metabolism
middle aged
pathology
sexual characteristics
signal transduction
very elderly
Dentistry
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Li, Chenshuang
Zheng, Zhong
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Abstract

As the leading cause of disability, osteoarthritis (OA) affects people of all ages, sexes, and races. With the increasing understanding of OA, the sex differences have attracted specific attention as the burden of OA is greater in women. There is no doubt that gender-specific OA management has great potential for precision treatment. On the other hand, from the marketing aspect, a medication targeting the OA-responsive biomarker(s) shared by both genders is more favorable for drug development. Thus, in the current study, a published transcriptome dataset of knee articular cartilage was used to compare OA and healthy samples for identifying the genes with the same significantly different expression trend in both males and females. With 128 genes upregulated and 143 genes downregulated in both OA males and females, 9 KEGG pathways have been enriched based on the current knowledge, including ‘renal cell carcinoma,’ ‘ECM-receptor interaction,’ ‘HIF-1 signaling pathway,’ ‘MicroRNAs in cancer,’ ‘focal adhesion,’ ‘Relaxin signaling pathway,’ ‘breast cancer,’ ‘PI3K-Akt signaling pathway,’ and ‘human papillomavirus infection.’ Here, we explore the potential impacts of these clusters in OA. We also analyze the identified ‘cell plasma membrane related genes’ in-depth to identify the potential chondrocyte cell surface target(s) of OA management. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

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2021-01-02
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International Journal of Molecular Sciences
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