Departmental Papers (Dental)

Document Type

Journal Article

Date of this Version


Publication Source

International Journal of Cancer





Start Page


Last Page





Tobacco smoke and its metabolites are carcinogens that increase tissue oxidative stress and induce target tissue inflammation. We hypothesized that genetic variation of inflammatory pathway genes plays a role in tobacco-related carcinogenesis and is modified by tobacco smoking. We evaluated the association of 12 single nucleotide polymorphisms of 8 inflammation-related genes with tobacco-related cancers (lung, oropharynx, larynx, esophagus, stomach, liver, bladder, and kidney) using 3 case-control studies from: Los Angeles (population-based; 611 lung and 553 upper aero-digestive tract cancer cases and 1,040 controls), Taixing, China (population-based; 218 esophagus, 206 stomach, 204 liver cancer cases, and 415 controls), and Memorial Sloan-Kettering Cancer Center (hospital-based; 227 bladder cancer cases and 211 controls). After adjusting for age, education, ethnicity, gender, and tobacco smoking, IL10 rs1800871 was inversely associated with oropharyngeal cancer (CT+TT vs. CC adjusted odds ratio [aOR]: 0.69, 95% confidence interval [CI]: 0.50-0.95), and was positively associated with lung cancer among never smokers (TT vs. CT+CC aOR: 2.5, 95% CI: 1.3-5.1) and inversely with oropharyngeal cancer among ever smokers (CT+TT vs. CC aOR: 0.63, 95% CI: 0.41-0.95). Among all pooled never smokers (588 cases and 816 controls), TNF rs1799964 was inversely associated with smoking-related cancer (CC vs. CT+TT aOR: 0.36, 95% CI: 0.17-0.77). Bayesian correction for multiple comparisons suggests that chance is unlikely to explain our findings (although epigenetic mechanisms may be in effect), which support our hypotheses, suggesting that IL10 rs1800871 is a susceptibility marker for oropharyngeal and lung cancers, and that TNF rs1799964 is associated with smoking-related cancers among never smokers. © 2010 UICC.


At the time of publication, author Anh Le was affiliated with the School of Dentistry, University of Southern California. Currently, (s)he is a faculty member at the School of Dental Medicine at the University of Pennsylvania.


Author keywords: IL10, inflammation, single nucleotide polymorphisms, TNF, tobacco-related cancer MeSH: Adult, Case-Control Studies, Female, Humans, Inflammation, Laryngeal Neoplasms, Lung Neoplasms, Male, Middle Aged, Neoplasms, Oropharyngeal Neoplasms, Polymorphism, Single Nucleotide, Smoking EMTREE drug terms: gamma interferon, gamma interferon receptor 1, interleukin 10, interleukin 1beta, tumor necrosis factor EMTREE medical terms: adult, age, article, Bayesian learning, bladder cancer, cancer susceptibility, carcinogenesis, China, controlled study, education, epigenetics, esophagus cancer, ethnicity, female, gender, genetic association, genetic variability, human, inflammation, kidney cancer, larynx cancer, liver cancer, lung cancer, major clinical study, male, neoplasm, oropharynx cancer, priority journal, single nucleotide polymorphism, smoking, stomach cancer, United States, case control study, genetics, larynx tumor, lung tumor, middle aged, oropharynx tumor



Date Posted: 09 February 2023

This document has been peer reviewed.