Single Nucleotide Polymorphisms of 8 Inflammation-related Genes and their Associations with Smoking-related Cancers
Penn collection
Degree type
Discipline
Subject
inflammation
single nucleotide polymorphisms
TNF
tobacco-related cancer MeSH: Adult
Case-Control Studies
Female
Humans
Inflammation
Laryngeal Neoplasms
Lung Neoplasms
Male
Middle Aged
Neoplasms
Oropharyngeal Neoplasms
Polymorphism
Single Nucleotide
Smoking EMTREE drug terms: gamma interferon
gamma interferon receptor 1
interleukin 10
interleukin 1beta
tumor necrosis factor EMTREE medical terms: adult
age
article
Bayesian learning
bladder cancer
cancer susceptibility
carcinogenesis
China
controlled study
education
epigenetics
esophagus cancer
ethnicity
female
gender
genetic association
genetic variability
human
inflammation
kidney cancer
larynx cancer
liver cancer
lung cancer
major clinical study
male
neoplasm
oropharynx cancer
priority journal
single nucleotide polymorphism
smoking
stomach cancer
United States
case control study
genetics
larynx tumor
lung tumor
middle aged
oropharynx tumor
Dentistry
Oral Biology and Oral Pathology
Other Dentistry
Periodontics and Periodontology
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Abstract
Tobacco smoke and its metabolites are carcinogens that increase tissue oxidative stress and induce target tissue inflammation. We hypothesized that genetic variation of inflammatory pathway genes plays a role in tobacco-related carcinogenesis and is modified by tobacco smoking. We evaluated the association of 12 single nucleotide polymorphisms of 8 inflammation-related genes with tobacco-related cancers (lung, oropharynx, larynx, esophagus, stomach, liver, bladder, and kidney) using 3 case-control studies from: Los Angeles (population-based; 611 lung and 553 upper aero-digestive tract cancer cases and 1,040 controls), Taixing, China (population-based; 218 esophagus, 206 stomach, 204 liver cancer cases, and 415 controls), and Memorial Sloan-Kettering Cancer Center (hospital-based; 227 bladder cancer cases and 211 controls). After adjusting for age, education, ethnicity, gender, and tobacco smoking, IL10 rs1800871 was inversely associated with oropharyngeal cancer (CT+TT vs. CC adjusted odds ratio [aOR]: 0.69, 95% confidence interval [CI]: 0.50-0.95), and was positively associated with lung cancer among never smokers (TT vs. CT+CC aOR: 2.5, 95% CI: 1.3-5.1) and inversely with oropharyngeal cancer among ever smokers (CT+TT vs. CC aOR: 0.63, 95% CI: 0.41-0.95). Among all pooled never smokers (588 cases and 816 controls), TNF rs1799964 was inversely associated with smoking-related cancer (CC vs. CT+TT aOR: 0.36, 95% CI: 0.17-0.77). Bayesian correction for multiple comparisons suggests that chance is unlikely to explain our findings (although epigenetic mechanisms may be in effect), which support our hypotheses, suggesting that IL10 rs1800871 is a susceptibility marker for oropharyngeal and lung cancers, and that TNF rs1799964 is associated with smoking-related cancers among never smokers. © 2010 UICC.