Departmental Papers (Dental)

Document Type

Journal Article

Date of this Version


Publication Source

Progress in Retinal and Eye Research






The retinal pigment epithelium (RPE), a monolayer of post-mitotic polarized epithelial cells, strategically situated between the photoreceptors and the choroid, is the primary caretaker of photoreceptor health and function. Dysfunction of the RPE underlies many inherited and acquired diseases that cause permanent blindness. Decades of research have yielded valuable insight into the cell biology of the RPE. In recent years, new technologies such as live-cell imaging have resulted in major advancement in our understanding of areas such as the daily phagocytosis and clearance of photoreceptor outer segment tips, autophagy, endolysosome function, and the metabolic interplay between the RPE and photoreceptors. In this review, we aim to integrate these studies with an emphasis on appropriate models and techniques to investigate RPE cell biology and metabolism, and discuss how RPE cell biology informs our understanding of retinal disease. © 2020 Elsevier Ltd


Autophagy; Endosomes; Lysosomes; Metabolism; Organelles; Phagocytosis; Phagosome maturation

Included in

Dentistry Commons



Date Posted: 08 December 2022

This document has been peer reviewed.