Aggregatibacter Actinomycetemcomitans Leukotoxin Utilizes a Cholesterol Recognition/Amino Acid Consensus Site for Membrane Association
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Departmental Papers (Dental)
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Amino Acid Motifs; Bacterial Toxins; Cholesterol; Exotoxins; Humans; Jurkat Cells; Lymphocyte Function-Associated Antigen-1; Membrane Microdomains; Pasteurellaceae; Protein Binding; Surface Plasmon Resonance
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Dentistry
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Brown, Angela C.
Balashova, Angela C.
Epand, Richard M.
Epand, Raquel F.
Bragin, Alvina
Kachlany, Scott C.
Walters, Michael J.
Du, Yurong
Boesze-Battaglia, Kathleen
Lally, Edward T.
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Abstract
Background: A repeats-in-toxin (RTX) leukotoxin and its integrin receptor aggregate in cholesterol-rich lipid rafts. Results: The affinity of the toxin to cholesterol is driven by a cholesterol recognition/amino acid consensus (CRAC) motif. Conclusion: Leukotoxin cytotoxicity is regulated by the CRAC motif. Significance: Other RTX toxins contain this CRAC motif, suggesting a role for cholesterol recognition in RTX cytolysis. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.
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2013-08-09
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Journal of Biological Chemistry