Departmental Papers (Dental)
Document Type
Review
Date of this Version
4-16-2021
Publication Source
Frontiers in Immunology
Volume
12
Start Page
Article number 667221
DOI
10.3389/fimmu.2021.667221
Abstract
A unique subpopulation of mesenchymal stem cells (MSCs) has been isolated and characterized from human gingival tissues (GMSCs). Similar to MSCs derived from other sources of tissues, e.g. bone marrow, adipose or umbilical cord, GMSCs also possess multipotent differentiation capacities and potent immunomodulatory effects on both innate and adaptive immune cells through the secretion of various types of bioactive factors with immunosuppressive and anti-inflammatory functions. Uniquely, GMSCs are highly proliferative and have the propensity to differentiate into neural cell lineages due to the neural crest-origin. These properties have endowed GMSCs with potent regenerative and therapeutic potentials in various preclinical models of human disorders, particularly, some inflammatory and autoimmune diseases, skin diseases, oral and maxillofacial disorders, and peripheral nerve injuries. All types of cells release extracellular vesicles (EVs), including exosomes, that play critical roles in cell-cell communication through their cargos containing a variety of bioactive molecules, such as proteins, nucleic acids, and lipids. Like EVs released by other sources of MSCs, GMSC-derived EVs have been shown to possess similar biological functions and therapeutic effects on several preclinical diseases models as GMSCs, thus representing a promising cell-free platform for regenerative therapy. Taken together, due to the easily accessibility and less morbidity of harvesting gingival tissues as well as the potent immunomodulatory and anti-inflammatory functions, GMSCs represent a unique source of MSCs of a neural crest-origin for potential application in tissue engineering and regenerative therapy. © Copyright © 2021 Kim, Lee, Xu, Zhang and Le.
Keywords
anti-inflammation, gingiva-derived mesenchymal stem cells, immunomodulation, neural crest, regenerative therapy, Cell Communication; Cell Differentiation; Cells, Cultured, Gingiva, Humans, Immunomodulation, Mesenchymal Stem Cells, Regenerative Medicine, Tissue Engineering
Recommended Citation
Kim, D., Lee, A. E., Xu, Q., Zhang, Q., & Le, A. D. (2021). Gingiva-Derived Mesenchymal Stem Cells: Potential Application in Tissue Engineering and Regenerative Medicine - A Comprehensive Review. Frontiers in Immunology, 12 Article number 667221-. http://dx.doi.org/10.3389/fimmu.2021.667221
Date Posted: 08 June 2022
This document has been peer reviewed.