Departmental Papers (Dental)

Document Type

Journal Article

Date of this Version

10-2015

Publication Source

Trends in Plant Science

Volume

20

Issue

10

Start Page

622

Last Page

640

DOI

10.1016/j.tplants.2015.07.004

Abstract

Chloroplasts are known to sustain life on earth by providing food, fuel and oxygen through the process of photosynthesis. However, the chloroplast genome has also been smartly engineered to confer valuable agronomic traits and/or serve as bioreactors for production of industrial enzymes, biopharmaceuticals, bio-products or vaccines. The recent breakthrough in hyper-expression of biopharmaceuticals in edible leaves has facilitated the advancement to clinical studies by major pharmaceutical companies. This review critically evaluates progress in developing new tools to enhance or simplify expression of targeted genes in chloroplasts. These tools hold the promise to further the development of novel fuels and products, enhance the photosynthetic process, and increase our understanding of retrograde signaling and cellular processes.

Copyright/Permission Statement

© <2015>. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/

Keywords

biofuels, biopharmaceuticals, molecular farming, metabolic engineering, biotic/abiotic stress tolerance, retrograde signaling

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Date Posted: 01 March 2022

This document has been peer reviewed.