Departmental Papers (Dental)

Document Type

Journal Article

Date of this Version

6-15-2013

Publication Source

Advanced Drug Delivery Reviews

Volume

65

Issue

6

Start Page

782

Last Page

799

DOI

10.1016/j.addr.2012.10.005

Abstract

Among 12 billion injections administered annually, unsafe delivery leads to >20 million infections and >100 million reactions. In an emerging new concept, freeze-dried plant cells (lettuce) expressing vaccine antigens/biopharmaceuticals are protected in the stomach from acids/enzymes but are released to the immune or blood circulatory system when plant cell walls are digested by microbes that colonize the gut. Vaccine antigens bioencapsulated in plant cells upon oral delivery after priming, conferred both mucosal and systemic immunity and protection against bacterial, viral or protozoan pathogens or toxin challenge. Oral delivery of autoantigens was effective against complications of type 1diabetes and hemophilia, by developing tolerance. Oral delivery of proinsulin or exendin-4 expressed in plant cells regulated blood glucose levels similar to injections. Therefore, this new platform offers a low cost alternative to deliver different therapeutic proteins to combat infectious or inherited diseases by eliminating inactivated pathogens, expensive purification, cold storage/transportation and sterile injections.

Copyright/Permission Statement

© <2013>. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/

Comments

At the time of publication, author Henry Daniell was affiliated with the University of Central Florida. Currently, he is a faculty member at the School of Dental Medicine at the University of Pennsylvania.

Keywords

Autoantigens, bioencapsulation, diabetes, hemophilia, infectious diseases, lyophilization, molecular farming, oral vaccines

Download

Included in

Dentistry Commons

Share

COinS
 

Date Posted: 01 March 2022

This document has been peer reviewed.