Departmental Papers (Dental)

Document Type

Journal Article

Date of this Version

6-15-2013

Publication Source

Advanced Drug Delivery Reviews

Volume

65

Issue

6

Start Page

759

Last Page

773

DOI

10.1016/j.addr.2012.10.013

Abstract

Oral tolerance is defined as the specific suppression of humoral and / or cellular immune responses to an antigen by administration of the same antigen through the oral route. Due to its absence of toxicity, easy administration, and antigen specificity, oral tolerance is a very attractive approach to prevent unwanted immune responses that cause a variety of diseases or that complicate treatment of a disease. Many researchers have induced oral tolerance to efficiently treat autoimmune and inflammatory diseases in different animal models. However, clinical trials yielded limited success. Thus, understanding the mechanisms of oral tolerance induction to therapeutic proteins is critical for paving the way for clinical development of oral tolerance protocols. This review will summarize progress on understanding the major underlying tolerance mechanisms and contributors, including antigen presenting cells, regulatory T cells, cytokines, and signaling pathways. Potential applications, examples for therapeutic proteins and disease targets, and recent developments in delivery methods are discussed.

Copyright/Permission Statement

© <2013>. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/

Comments

At the time of publication, author Henry Daniell was affiliated with the University of Central Florida. Currently, he is a faculty member at the School of Dental Medicine at the University of Pennsylvania.

Keywords

oral tolerance, dendritic cells, Treg, IL-10, TGF-β, Tr1, Th3, nanoparticles, transgenic plants, oral delivery, protein antigen

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Date Posted: 01 March 2022

This document has been peer reviewed.