Departmental Papers (Dental)

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Journal Article

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Oral Microbiology and Immunology





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Actinobacillus actinomycetemcomitans was acquired by captive Macaca fascicularis 3 to 6 months after birth, and all monkeys aged over 6 months harbored detectable levels. This microorganism was most frequently isolated from the gingival plaque of the incisor (and other) teeth compared with other oral sites. Strains were leukotoxic by bioassay and Western blot analysis. Antibodies in macaque serum contained neutralized the leukotoxin of a human A. actinomycetemcomitans strain. High titres of maternal neutralizing anti-leukotoxin antibodies were detected in neonates; the titre then fell rapidly so that by 6 months the antibody titer was zero. Antileukotoxin antibody production was detected after 6 months of age, rapidly reaching a high level within 2 years after birth. The presence of leukotoxic strains of A. actinomycetemcomitans in the gingival region did not appear to be correlated with an increase in susceptibility to periodontal disease.

Copyright/Permission Statement

This is the pre-peer reviewed version of the following article: [Beighton, David & S. Taichman, Norton & L. Simpson, David & M. Dirienzo, Joseph & Johnson, Newell. (1989). Intra-oral colonization of macaque monkeys by Actinobacillus actinomycetemcomitans. Oral microbiology and immunology. 4. 35-40. 10.1111/j.1399-302X.1989.tb00404.x. ], which has been published in final form in Oral Microbiology and Immunology. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.


non-human primates, Actinobacillus actinomycetemcomitans, leukotoxin, colonization, maternal antibody

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Dentistry Commons



Date Posted: 01 March 2022

This document has been peer reviewed.