Date of this Version
Journal of Dental Research
β-catenin signaling is required for embryonic tooth morphogenesis and promotes continuous tooth development when activated in embryos. To determine whether activation of this pathway in the adult oral cavity could promote tooth development, we induced mutation of epithelial β-catenin to a stabilized form in adult mice. This caused increased proliferation of the incisor tooth cervical loop, outpouching of incisor epithelium, abnormal morphology of the epithelial-mesenchymal junction, and enhanced expression of genes associated with embryonic tooth development. Ectopic dental-like structures were formed from the incisor region following implantation into immunodeficient mice. Thus, forced activation of β-catenin signaling can initiate an embryonic-like program of tooth development in adult rodent incisor teeth.
Akintoye, Sunday, β-catenin Initiates Tooth Neogenesis in Adult Rodent Incisors, Journal of Dental Research (89 & 9) pp. 909–914. Copyright @  (International & American Associations for Dental Research). Reprinted by permission of Sage Publications.
tooth, development, β-catenin, Wnt, dental
Liu, F., Dangaria, S., Andl, T., Zhang, Y., Wright, A., Damek-Poprawa, M., Piccolo, S., Nagy, A., Taketo, M., Diekwisch, T., Miller, S., & Akintoye, S. (2010). β-catenin Initiates Tooth Neogenesis in Adult Rodent Incisors. Journal of Dental Research, 89 (9), 909-914. http://dx.doi.org/10.1177/0022034510370090
Date Posted: 01 March 2022
This document has been peer reviewed.