Departmental Papers (Dental)
Document Type
Journal Article
Date of this Version
4-2008
Publication Source
Stem Cells
Volume
26
Issue
4
Start Page
1065
Last Page
1073
DOI
10.1634/stemcells.2007-0734
Abstract
Periodontitis is a periodontal tissue infectious disease and the most common cause for tooth loss in adults. It has been linked to many systemic disorders, such as coronary artery disease, stroke, and diabetes. At present, there is no ideal therapeutic approach to cure periodontitis and achieve optimal periodontal tissue regeneration. In this study, we explored the potential of using autologous periodontal ligament stem cells (PDLSCs) to treat periodontal defects in a porcine model of periodontitis. The periodontal lesion was generated in the first molars area of miniature pigs by the surgical removal of bone and subsequent silk ligament suture around the cervical portion of the tooth. Autologous PDLSCs were obtained from extracted teeth of the miniature pigs and then expanded ex vivo to enrich PDLSC numbers. When transplanted into the surgically created periodontal defect areas, PDLSCs were capable of regenerating periodontal tissues, leading to a favorable treatment for periodontitis. This study demonstrates the feasibility of using stem cell-mediated tissue engineering to treat periodontal diseases.
Copyright/Permission Statement
This is the pre-peer reviewed version of the following article: [Liu, Y., Zheng, Y., Ding, G., Fang, D., Zhang, C., Bartold, P. M., . . . Wang, S. (2008). Periodontal ligament stem Cell‐Mediated treatment for periodontitis in miniature swine. Stem Cells, 26(4), 1065-1073. doi:10.1634/stemcells.2007-0734], which has been published in final form at [http://dx.doi.org/10.1634/stemcells.2007-0734]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Keywords
Periodontal ligament stem cells, Periodontal disease, Tissue engineering, Regeneration Go to:
Recommended Citation
Liu, Y., Zheng, Y., Ding, G., Fang, D., Zhang, C., Bartold, P. M., Gronthos, S., Shi, S., & Wang, S. (2008). Periodontal Ligament Stem Cell-Mediated Treatment for Periodontitis in Miniature Swine. Stem Cells, 26 (4), 1065-1073. http://dx.doi.org/10.1634/stemcells.2007-0734
Date Posted: 01 March 2022
This document has been peer reviewed.
Comments
At the time of publication, author Songtao Shi was affiliated with the University of Southern California. Currently, he is a faculty member at the School of Dental Medicine at the University of Pennsylvania