Document Type

Journal Article

Date of this Version

2013

Publication Source

BioMed Research International

Volume

2013

Start Page

Article ID 754802

DOI

10.1155/2013/754802

Abstract

Impaired diabetic wound healing constitutes a major health problem. The impaired healing is caused by complex factors such as abnormal keratinocyte and fibroblast migration, proliferation, differentiation, and apoptosis, abnormal macrophage polarization, impaired recruitment of mesenchymal stem cells (MSCs) and endothelial progenitor cells (EPCs), and decreased vascularization. Diabetes-enhanced and prolonged expression of TNF-α also contributes to impaired healing. In this paper, we discuss the abnormal cell responses in diabetic wound healing and the contribution of TNF-α.

Copyright/Permission Statement

Copyright © 2013 Fanxing Xu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Keywords

Animals, Cell Differentiation, Cell Proliferation, Diabetes Mellitus, Fibroblasts, Gene Expression Regulation, Humans, Keratinocytes, Macrophages, Mesenchymal Stromal Cells, Tumor Necrosis Factor-alpha, Wound Healing

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Date Posted: 02 April 2015

This document has been peer reviewed.