Departmental Papers (Dental)
Document Type
Journal Article
Date of this Version
2013
Publication Source
BioMed Research International
Volume
2013
Start Page
Article ID 754802
DOI
10.1155/2013/754802
Abstract
Impaired diabetic wound healing constitutes a major health problem. The impaired healing is caused by complex factors such as abnormal keratinocyte and fibroblast migration, proliferation, differentiation, and apoptosis, abnormal macrophage polarization, impaired recruitment of mesenchymal stem cells (MSCs) and endothelial progenitor cells (EPCs), and decreased vascularization. Diabetes-enhanced and prolonged expression of TNF-α also contributes to impaired healing. In this paper, we discuss the abnormal cell responses in diabetic wound healing and the contribution of TNF-α.
Copyright/Permission Statement
Copyright © 2013 Fanxing Xu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords
Animals, Cell Differentiation, Cell Proliferation, Diabetes Mellitus, Fibroblasts, Gene Expression Regulation, Humans, Keratinocytes, Macrophages, Mesenchymal Stromal Cells, Tumor Necrosis Factor-alpha, Wound Healing
Recommended Citation
Xu, F., Zhang, C., & Graves, D. T. (2013). Abnormal Cell Repsonses and Role of TNF-α in Impaired Diabetic Wound Healing. BioMed Research International, 2013 Article ID 754802-. http://dx.doi.org/10.1155/2013/754802
Date Posted: 02 April 2015
This document has been peer reviewed.