Document Type

Journal Article

Date of this Version

2012

Publication Source

Experimental Diabetes Research

Volume

2012

Start Page

Article ID 939751

DOI

10.1155/2012/939751

Abstract

Diabetes is a chronic metabolic disorder, characterized by hyperglycemia resulting from insulin deficiency and/or insulin resistance. Recent evidence suggests that high levels of reactive oxygen species (ROS) and subsequent oxidative stress are key contributors in the development of diabetic complications. The FOXO family of forkhead transcription factors including FOXO1, FOXO3, FOXO4, and FOXO6 play important roles in the regulation of many cellular and biological processes and are critical regulators of cellular oxidative stress response pathways. FOXO1 transcription factors can affect a number of different tissues including liver, retina, bone, and cell types ranging from hepatocytes to microvascular endothelial cells and pericytes to osteoblasts. They are induced by oxidative stress and contribute to ROS-induced cell damage and apoptosis. In this paper, we discuss the role of FOXO transcription factors in mediating oxidative stress-induced cellular response.

Copyright/Permission Statement

Copyright © 2012 Bhaskar Ponugoti et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Keywords

Diabetes Mellitus, Forkhead Transcription Factors, Humans, Liver, Oxidative Stress, Reactive Oxygen Species

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Date Posted: 02 April 2015

This document has been peer reviewed.