Departmental Papers (Dental)
The Hidden Treasure in Apical Papilla: The Potential Role in Pulp/Dentin Regeneration and BioRoot Engineering
Date of this Version
Journal of Endodontics
Some clinical case reports have shown that immature permanent teeth with periradicular periodontitis or abscess can undergo apexogenesis after conservative endodontic treatment. A call for a paradigm shift and new protocol for the clinical management of these cases has been brought to attention. Concomitantly, a new population of mesenchymal stem cells residing in the apical papilla of permanent immature teeth recently has been discovered and was termed stem cells from the apical papilla (SCAP). These stem cells appear to be the source of odontoblasts that are responsible for the formation of root dentin. Conservation of these stem cells when treating immature teeth may allow continuous formation of the root to completion. This article reviews current findings on the isolation and characterization of these stem cells. The potential role of these stem cells in the following respects will be discussed: (1) their contribution in continued root maturation in endodontically treated immature teeth with periradicular periodontitis or abscess and (2) their potential utilization for pulp/dentin regeneration and bioroot engineering.
©<2008>. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Apexogenesis, apical papilla, bioroot engineering, dental pulp stem cells, immature teeth, periodontal ligament stem cells, pulp regeneration, stem cells from human exfoliated deciduous teeth, stem cells from the apical papilla
Huang, G. T., Sonoyama, W., Liu, Y., Liu, H., Wang, S., & Shi, S. (2008). The Hidden Treasure in Apical Papilla: The Potential Role in Pulp/Dentin Regeneration and BioRoot Engineering. Journal of Endodontics, 34 (6), 645-651. http://dx.doi.org/10.1016/j.joen.2008.03.001
Date Posted: 01 March 2022
This document has been peer reviewed.
At the time of publication, author Songtao Shi was affiliated with the University of Southern California. Currently, he is a faculty member at the School of Dental Medicine at the University of Pennsylvania.