Departmental Papers (Dental)

 
Penn Dental Medicine views scholarship as a central component of excellence in instruction and patient care and places a high priority on research. The School’s research enterprise spans scientific disciplines to translate new knowledge into clinical therapies that positively impact our understanding of oral disease and advance patient care.

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Submissions from 2018

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RANKL Deletion in Periodontal Ligament and Bone Lining Cells Blocks Orthodontic Tooth Movement, Chia-Ying Yang, Hyeran H. Jeon, Ahmed Alshabab, Yu Jin Lee, and Chun-Hsi Chung

Submissions from 2017

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Canine Mesenchymal Stem Cell Bone Regenerative Capacity is Regulated by Site-Specific Multi-Lineage Differentiation, Juan Bugueno, Weihua Li, Pinky Salat, Ling Qin, and Sunday O. Akintoye

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Subgingival Microbiota Dysbiosis in Systemic Lupus Erythematosus: Association with Periodontal Status, Jôice Dias Corrêa, Débora Cerqueira Calderaro, Gilda Aparecida Ferreira, Santuza Maria Souza Mendonça, Gabriel R. Fernandes, E Xiao, Antônio Lúcio Teixeira, Eugene J. Leys, Dana T. Graves, and Tarcília Aparecida Silva

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FOXO1 Regulates Bacteria-Induced Neutrophil Activity, Guangyu Dong, Liang Song, Chen Tian, Yu Wang, Fang Miao, Jiabao Zheng, Chanyi Lu, Sarah Alsadun, and Dana T. Graves

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TNFα Contributes to Diabetes Impaired Angiogenesis in Fracture Healing, Jason C. Lim, Kang I. Ko, Marcelo Mattos, Miao Fang, Citong Zhang, Daniel Feinberg, Hisham Sindi, Shuai Li, Jazia Alblowi, Rayyan A. Kayal, Thomas A. Einhorn, Louis Gerstenfeld, and Dana Graves

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FOXO1 Deletion in Keratinocytes Improves Diabetic Wound Healing through MMP9 Regulation, Chenying Zhang, Jason Lim, Hyeran H. Jeon, Fanxing Xu, Chen Tian, Fang Miao, Alhassan Hameedaldeen, and Dana T. Graves

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FOXO1 Expression in Keratinocytes Promotes Connective Tissue Healing, Chenying Zhang, Jason Lim, Jian Liu, Bhaskar Ponugoti, Sarah Alsadun, Chen Tian, Rameen Vafa, and Dana T. Graves

Submissions from 2016

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Impact of Communication Between Physicians and Dentists on the Incidence of Jaw Osteonecrosis Caused by Bone Anti-Resorptives, Sunday O. Akintoye and Elliot V. Hersh

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Diabetes and Increased Lipid Peroxidation are Associated with Systemic Inflammation Even in Well-Controlled Patients, Alliny de Souza Bastos, Dana T. Graves, Ana Paula de Melo Louireiro, Carlos Rossa Jr, Samia Cruz Tfaile Corbi, Fausto Frizzera, Raquel Mantuaneli Scarel-Caminaga, Niels Olsen-Camara, Oelisoa M. Andriankaja, Meire I. Hiyane, and Silvana Regina Perez Orrico

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Penn Endo Surgical Documentation Guidelines, Bekir Karabucak

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Biocompatibility of two Experimental Scaffolds for Regenerative Endodontics, Dephne Jack Zin Leong, Frank Setzer, Martin Trope, and Bekir Karabucak

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Chemical and Radiation Associated Jaw Lesions, Temitope T. Omolehinwa and Sunday O. Akintoye

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Incidental Finding of an Extensive Oropharyngeal Mass in Magnetic Resonance Imaging of a Patient With Temporomandibular Disorder: A Case Report, Temitope T. Omolehinwa, Mel Mupparapu, and Sunday O. Akintoye

Submissions from 2015

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The Enduring Importance of Animal Models in Understanding Periodontal Disease, George Hajishengallis, Richard J. Lamont, and Dana T. Graves

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Diabetes and its Effect on Bone and Fracture Healing, Hongli Jiao, E Xiao, and Dana T. Graves

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Diabetes Reduces Mesenchymal Stem Cells in Fracture Healing Through a TNFα-Mediated Mechanism, Kang I. Ko, Leila S. Coimbra, Chen Tian, Jazia Alblowi, Rayyan A. Kayal, Thomas A. Einhorn, Louis C. Gerstenfeld, Robert J. Pignolo, and Dana T. Graves

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Osteoblast Lineage Cells Play an Essential Role in Periodontal Bone Loss Through Activation of Nuclear Factor-Kappa B., Sandra Pacios, Wenmei Xiao, Marcelo Mattos, Jason Lim, Rohinton S. Tarapore, Sarah Alsadun, Bo Yu, Cun-Yu Wang, and Dana T. Graves

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Diabetes Mellitus Related Bone Metabolism and Periodontal Disease, Ying-Ying Wu, E Xiao, and Dana T. Graves

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FOXO1 Deletion Reduces Dendritic Cell Function and Enhances Susceptibility to Periodontitis, Wenmei Xiao, Guangyu Dong, Sandra Pacios, Maher Alnammary, Laura A. Barger, Yu Wang, Yingying Wu, and Dana T. Graves

Submissions from 2014

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Dental Perspectives in Fibrous Dysplasia and McCune-Albright Syndrome, Sunday O. Akintoye, Alison M. Boyce, and Michael T. Collins

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Role of Fas and Treg Cells in Fracture Healing as Characterized in the Fas-Deficient (lpr) Mouse Model of Lupus, Maisa O. Al-Sebaei, Dana M. Daukss, Anna C. Belkina, Sanjeev Kakar, Nathan A. Wigner, Daniel Crusher, Dana T. Graves, Thomas Einhorn, Elise Morgan, and Louis C. Gerstenfeld

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Effect of Bacteria on the Wound Healing Behavior of Oral Epithelial Cells, Rupa Bhattacharya, Fanxing Xu, Guangyu Dong, Shuai Li, Chen Tian, Bhaskar Ponugoti, and Dana T. Graves

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PTH1-34 Alleviates Radiotherapy-Induced Local Bone Loss by Improving Osteoblast and Osteocyte Survival, Abhishek Chandra, Tiao Lin, Mary Beth Tribble, Jhi Zhu, Allison R. Altman, Weiju Tseng, Yejia Zhang, Sunday O. Akintoye, Keith Cengel, X. Sherry Liu, and Ling Qin

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Clopidogrel Enhances Periodontal Repair in Rats Through Decreased Inflammation, Leila S. Coimbra, Joao Paulo Steffens, Carlos Rossa Jr., Dana T. Graves, and Luis C. Spolidorio

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FOXO1, TGF-β Regulation and Wound Healing, Alhassan Hameedaldeen, Jian Liu, Angelika Batres, Gabrielle S. Graves, and Dana T. Graves

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A Comparison of Dimensional Standard of Several Nickel-Titanium Rotary Files, Ki-Won Kim, Kyung-Mo Cho, Se-Hee Park, Ki-Yeol Choi, Bekir Karabucak, and Jin-Woo Kim

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FOXO Transcription Factors: Their Clinical Significance and Regulation, Yu Wang, Yanmin Zhou, and Dana T. Graves

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Wnt4 Signaling Prevents Skeletal Aging and Inflammation by Inhibiting Nuclear Factor-κB, Bo Yu, Jia Chang, Jiong Li, Kareena Kevork, Khalid Al-Hezaimi, Dana T. Graves, No-Hee Park, and Cun-Yu Wang

Submissions from 2013

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Chemokine Expression Is Upregulated in Chondrocytes in Diabetic Fracture Healing, Jazia Alblowi, Chen Tian, Rayyan A. Kayal, Erin McKenzie, Yugal Behl, Louis Gerstenfeld, Thomas A. Einhorn, and Dana T. Graves

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Onset of Mandible and Tibia Osteoradionecrosis – a Comparative Pilot Study in the rat, Monika Damek-Poprawa, Stefan Booth, Alexander C. Wright, Amit Maity, and Sunday O. Akintoye

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An Evaluation of 10 Percent and 20 Percent Benzocaine Gels in Patients With Acute Toothaches: Efficacy, Tolerability and Compliance With Label Dose Administration Directions, Elliot V. Hersh, Sebastian G. Ciancio, Arthur S. Kuperstein, Eric T. Stoopler, Paul A. Moore, Sean G. Boynes, Steven C. Levine, Paul Casamassimo, Rina Leyva, Tanya Mathew, Othman Shibly, Paul Creighton, Gary E. Jeffers, Patricia M. A Corby, Stanley N. Turetzky, Athena Papas, Jillian Wallen, Cynthia Idzik-Starr, and Sharon M. Gordon

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P. gingivalis Modulates Keratinocytes Through FOXO Transcription Factors, Shuai Li, Guangyu Dong, Anastasios Moschidis, Javier Ortiz, Manjunatha R. Benakanakere, Denis F. Kinane, and Dana T. Graves

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Bacterial Infection Increases Periodontal Bone Loss in Diabetic Rats Through Enhanced Apoptosis, Sandra Pacios, Oelisoa Andriankaja, Jun Kang, Maher Alnammary, Jason Bae, Beatriz de Brito Bezerra, Helen Schreiner, Daniel H. Fine, and Dana T. Graves

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FOXO1 Promotes Wound Healing Through the Up-Regulation of TGF-β1 and Prevention of Oxidative Stress, Bhaskar Ponugoti, Fanxing Xu, Chenying Zhang, Chen Tian, Sandra Pacios, and Dana T. Graves

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Pemphigus, Frank A. Santoro, Eric T. Stoopler, and Victoria P. Werth

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Topical and Systemic Therapies for Oral and Perioral Herpes Simplex Virus Infections, Eric T. Stoopler and Ramesh Balasubramanlam

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Glossitis Secondary to Vitamin B12 Deficiency Anemia, Eric T. Stoopler and Arthur S. Kuperstein

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Recurrent Aphthous Stomatitis, Eric T. Stoopler and Thamer Musbah

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Household Laundry Detergent as a Possible Cause of Oral Lichenoid Lesions, Eric T. Stoopler and Christine Nadeau

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Temporomandibular Disorders, Eric T. Stoopler and Thomas P. Sollecito

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Osteonecrosis of the Jaw in a Patient Taking Once-Yearly Infusion of Zoledronic Acid for Osteopenia, Takako I. Tanaka and Charles D. Taylor

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Locally Delivered Salicylic Acid From a Poly(anhydride-ester): Impact on Diabetic Bone Regeneration, Keisuke Wada, Weling Yu, Mohamad Elaziz, Sandrine Barakat, Michelle A. Ouimet, Roselin Rosario-Meléndez, Joseph P. Fiorellini, Dana T. Graves, and Kathryn E. Uhrich

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Abnormal Cell Repsonses and Role of TNF-α in Impaired Diabetic Wound Healing, Fanxing Xu, Chenying Zhang, and Dana T. Graves

Submissions from 2012

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A.Actinomycetemcomitans‐Induced Periodontal Disease Promotes Systemic and Local Responses in Rat Periodontium, Beatriz de Brito Bezerra, Oelisoa Andriankaja, Jun Kang, Sandra Pacios, Hyung Jin Bae, Yu Li, Vincent Tsiagbe, Helen Schreiner, Daniel H. Fine, and Dana T. Graves

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Biomimetic Calcium-Silicate Cements Support Differentiation Of Human Orofacial Mesenchymal Stem Cells, Maria Giovanna Gandolfi, Sara N. Shah, Ruoxue Feng, Carlo Prati, and Sunday O. Akintoye

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Animal Models to Study Host-Bacteria Interactions Involved in Periodontitis, Dana T. Graves, Jun Kang, Oelisoa Andriankaja, Keisuke Wada, and Carlos Rossa Jr.

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Clinical Guidelines for the Management of Craniofacial Fibrous Dysplasia, J S. Lee, E J. FitzGibbon, Y R. Chen, H J. Kim, L R. Lustig, Sunday O. Akintoye, M T. Collins, and L B. Kaban

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Role of Forkhead Transcription Factors in Diabetes-Induced Oxidative Stress, Bhaskar Ponugoti, Guangyu Dong, and Dana T. Graves

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Pregnancy Gingivitis and Pregnancy Tumour, Eric T. Stoopler and Arthur S. Kuperstein

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Oral Lichen Planus, Eric T. Stoopler and Thomas P. Sollecito

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Effect of Body Composition and Renal Function on the Pharmacokinetics of High-Dose Melphalan for Multiple Myeloma, Dan T. Vogl, Rosemarie Mick, Eric T. Stoopler, Lisa E. Davis, Thomas M. Paul, German Salazar, Maria Raguza-Lopez, David L. Porter, Selina M. Luger, and Edward A. Stadtmauer

Submissions from 2011

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Interaction of Oral Bacteria With Gingival Epithelial Cell Multilayers, Brittany C. Dickinson, Catherine E. Moffatt, Dylan Hagerty, Sarah E. Whitmore, Thomas A. Brown, Dana T. Graves, and Richard J. Lamont

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Review of Osteoimmunology and the Host Response in Endodontic and Periodontal Lesions, Dana T. Graves, Thomas Oates, and Gustavo P. Garlet

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A Long-Term siRNA Strategy Regulates Fibronectin Overexpression and Improves Vascular Lesions in Retinas of Diabetic Rats, Sumon Roy, Sigrid Nasser, Dana T. Graves, and Sayon Roy

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FOXO1 Modulates Osteoblast Differentiation, Michelle F. Siqueira, Stephen Flowers, Rupa Bhattacharya, Dan Faibish, Yugal Behl, Darrell N. Kotton, Lou Gerstenfeld, Elizabeth Moran, and Dana T. Graves

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Human Papillomavirus Lesions of the Oral Cavity, Eric T. Stoopler and Ramesh Balasubramanlam

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Anatomic Site Variability in Rat Skeletal Uptake and Desorption Of Fluorescently Labeled Bisphosphonate, D. Wen, L. Qing, G. Harrison, E. Golub, and Sunday O. Akintoye

Submissions from 2010

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FOXO1 Plays an Essential Role in Apoptosis of Retinal Pericytes, Mani Alikhani, Sayon Roy, and Dana T. Graves

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Human Bone Marrow Stromal Cells Display Variable Anatomic Site-Dependent Response and Recovery From Irradiation, Monika Damek-Poprawa, Derek Stefanik, Lawrence Levin, and Sunday O. Akintoye

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Age and Skeletal Sites Affect BMP-2 Responsiveness of Human Bone Marrow Stromal Cells, Anna M. Osyczka, Monika Damek-Poprawa, Aleksandra Wojtowicz, and Sunday O. Akintoye

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Impaired Wound Healing in Mouse Models of Diabetes Is Mediated by TNF-α Dysregulation and Associated With Enhanced Activation of Forkhead Box O1 (FOXO1), Michelle F. Siqueira, Jingyuan Li, Leena Chehab, Tesfahun Desta, Takahiro Chino, N. Krothpali, Yugal Behl, Mani Alikhani, Julia Yang, Cameron Braasch, and Dana T. Graves

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Differentiation and Regenerative Capacities of Human Odontoma-Derived Mesenchymal Cells, Jin-Seon Song, Derek Stefanik, Monika Damek-Poprawa, Faizan Alawi, and Sunday O. Akintoye

Submissions from 2009

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BMP2 Is Essential for Post Natal Osteogenesis but Not for Recruitment of Osteogenic Stem Cells, Manish V. Bais, Nathan A. Wigner, Megan Young, Ryan Toholka, Dana T. Graves, Elise Feng Morgan, Louis Charles Gerstenfeld, and Thomas A. Einhorn

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Functional and Structural Characterization of Chimeras of a Bacterial Genotoxin and Human Type I DNAse, Joseph M. DiRienzo, Linsen Cao, Alla Volgina, Georges Bandelac, and Johnathan M. Korostoff

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Diabetes Causes the Accelerated Loss of Cartilage During Fracture Repair Which Is Reversed by Insulin Treatment, Rayyan A. Kayal, Jazia Alblowi, Erin McKenzie, Nanarao Krothapalli, Lee Silkman, Louis Gerstenfeld, Thomas Einhorn, and Dana T. Graves

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Evaluation of the Humoral Immune Response to the Cytolethal Distending Toxin of Aggregatibacter Actinomycetemcomitans Y4 in Subjects With Localized Aggressive Periodontitis, Ioanna Xynogala, Alla Volgina, Joseph M. DiRienzo, and Johnathan M. Korostoff

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Dynamic Hydrostatic Pressure Promotes Differentiation of Human Dental Pulp Stem Cells, V. Yu, M. Damek-Poprawa, S.B. Nicoll, and Sunday O. Akintoye

Submissions from 2008

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Comparative Osteogenesis of Maxilla and Iliac Crest Human Bone Marrow Stromal Cells Attached to Oxidized Titanium - a Pilot Study, Sunday O. Akintoye, Parascevi Giavis, Derek Stefanik, Lawrence Levin, and Francis K. Mante

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Molecular Mechanisms Controlling Bone Formation During Fracture Healing and Distraction Osteogenesis, Zainab S. Al-Aql, Adel S. Alagl, Dana T. Graves, Louis C. Gerstenfeld, and Thomas A. Einhorn

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The Use of Rodent Models to Investigate Host-Bacteria Interactions Related to Periodontal Diseases, Dana T. Graves, Daniel Fine, Yen-Tung A. Teng, Tom E. Van Dyke, and George Hajishengallis

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Effects of Maxillary Sinus Graft on the Survival of Endosseous Implants: A 10-Year Retrospective Study, Hyeran H. Jeon, Eun-Kyoung Pang, Ah-Ran Pae, Myung-Rae Kim, and Na-Ra Kang

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P. Gingivalis and E. Coli Lipopolysaccharides Exhibit Different Systemic but Similar Local Induction of Inflammatory Markers, Rongkun Liu, Tesfahun Desta, Markos Raptis, Richard P. Darveau, and Dana T. Graves

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Disparate Osteogenic Response of Mandible and Iliac Crest Bone Marrow Stromal Cells to Pamidronate, D. Stefanik, J. Sarin, T. Lam, L. Levin, P.S. Leboy, and Sunday O. Akintoye

Submissions from 2007

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Advanced Glycation End Products Stimulate Osteoblast Apoptosis Via the MAP Kinase and Cytosolic Apoptotic Pathways, Mani Alikhani, Zoubin Alikhani, Coy Boyd, Christine M. McLellan, Markos Raptis, Rongkun Liu, Nicole Pischon, Philip C. Trackman, Louis Gerstenfeld, and Dana T. Graves

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Fibroblast Apoptosis Induced by Porphyromonas Gingivalis is Stimulated by a Gingipain and Caspase-Independent Pathway that Involves Apoptosis-Inducing Factor, Tesfahun Desta and Dana T. Graves

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Apoptosis in Gingival Overgrowth Tissues, Alpdoǧan I. Kantarci, Peter Augustín, Erhan Firatli, Michael C. Sheff, Hatice Hastürk, Dana T. Graves, and Philip C. Trackman

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Diminished Bone Formation During Diabetic Fracture Healing Is Related to the Premature Resorption of Cartilage Associated with Increased Osteoclast Activity, Rayyan A. Kayal, Dimitris Tsatsas, Megan A. Bauer, Brian Allen, Maisa O. Al-Sebaei, Sanjeev Kakar, Catalado W. Leone, Elise F. Morgan, Louis C. Gerstenfeld, Thomas A. Einhorn, and Dana T. Graves

Submissions from 2006

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Experimental Study on the Acellular Demal Matrix Graft for the Root Coverage in Dog, Min-Young Cho, Seoung-Ho Lee, Keum-Ah Han, Jun-Young Lee, Hyeran H. Jeon, Na-Ra Kang, and Myung-Rae Kim

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The Effect of Ca-P Coated Bovine Bone Mineral on Bone Regeneration around Dental Implant in Dogs, Su-Yeon Cho, Hyeran H. Jeon, Sun-Kyoung Lee, Seoung-Ho Lee, Jun-Young Lee, and Keum-Ah Han

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Diabetes Enhances Periodontal Bone Loss Through Enhanced Resorption and Diminished Bone Formation, Rongkun Liu, Harbinder S. Bal, Tesfahun Desta, Nanarao Krothapalli, Monaf Alyassi, Qingxian Luan, and Dana T. Graves

Submissions from 2005

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Characterization of Point Mutations in the cdtA Gene of the Cytolethal Distending Toxin of Actinobacillus Actinomycetemcomitans, Linsen Cao, Alla Volgina, Chuang-ming Huang, Johnathan M. Korostoff, and Joseph M. DiRienzo

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Differential Effect of the Cytolethal Distending Toxin of Actinobacillus actinomycetemcomitans on Co-Cultures of Human Oral Cells, Philip Kang, Johnathan M. Korostoff, Alla Volgina, Wojciech Grzesik, and Joseph M. DiRienzo

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Anxiety Control and Periodontal Practice, Seoung-Ho Lee, Jun-Young Lee, Hyeran H. Jeon, and Gum-Aha Han

Submissions from 2004

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Signaling by EphrinB1 and Eph Kinases in Platelets Promotes Rap1 Activation, Platelet Adhesion, and Aggregation via Effector Pathways that Do Not Require Phosphorylation of EphrinB1, Nicolas Prévost, Donna S. Woulfe, Massimiliano Tognolini, and Takako I. Tanaka

Submissions from 2003

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Extensive Pneumatization of the Temporal Bone and Articular Eminence: An Incidental Finding in a Patient With Facial Pain. Case Report and Review of Literature, Eric T. Stoopler, Andres A. Pinto, David C. Stanton, Muralidhar Mupparapu, and Thomas P. Sollecito

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Desquamative Gingivitis: Early Presenting Symptom of Mucocutaneous Disease, Eric T. Stoopler, Thomas P. Sollecito, and Scott S. DeRossi

Submissions from 1990

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Neonatal Exposure to Thymotropic Gross Murine Leukemia Virus Induces Virus-Specific Immunologic Nonresponsiveness, Johnathan M. Korostoff, Marian T. Nakada, Susan J. Faas, Kenneth J. Blank, and Glen N. Gaulton