Penn Chemistry is a leading center of molecular research. Within the department, the traditional sub-fields of biochemistry, organic, inorganic, and physical chemistry serve as a framework from which collaborative, inter-disciplinary experimental and theoretical research is launched. Research thrusts include:
- Synthesis and Characterization of New Compounds and Materials
- Chemistry of Life Processes
- Nanoscale Materials and Molecular Devices
- Chemistry of the Environment
- Energy and the Hydrogen Economy
Submissions from 2016
The Role of Dynamic Ligand Exchange in the Oxidation Chemistry of Cerium(III), Jerome R. Robinson, Yusen Qiao, Jun Gu, Patrick J. Carroll, Patrick J. Walsh, and Eric J. Schelter
Submissions from 2015
Xe Affinities of Water-Soluble Cryptophanes and the Role of Confined Water, Lu Gao, Wenhao Liu, One-Sun Lee, Ivan J. Dmochowskia, and Jeffery G. Saven
Molecular Recognition of Ketamine by a Subset of Olfactory G Protein–coupled Receptors, Jianghai Ho, Jose Manuel Perez Aguilar, Lu Gao, Jeffery G. Saven, Hiroaki Matsunami, and Roderic G. Eckenhoff
Submissions from 2014
Scalable Production of Highly Sensitive Nanosensors Based on Graphene Functionalized With a Designed G Protein-Coupled Receptor, Mitchell Bryant Lerner, Felipe Matsunaga, Gang Hee Han, Sung Ju Hong, Jin Xi, Alexander Crook, Jose Manuel Perez Aguilar, Yung Woo Park, Jeffery G. Saven, Renyu Liu, and A. T. Charlie Johnson
Characterization of a Computationally Designed Water-Soluble Human μ Opioid Receptor Variant Using X-ray Structural Information, Xuelian Zhao, Jose Manuel Perez Aguilar, Felipe Matsunaga, Mitchell Bryant Lerner, Jin Xi, Bernard Selling, A. T. Charlie Johnson, Jeffery G. Saven, and Renyu Liu
Submissions from 2013
Computational De Novo Design and Characterization of a Protein That Selectively Binds a Highly Hyperpolarizable Abiological Chromophore, H Christopher Fry, Andreas Lehmann, Louise E. Sinks, Inge Asselberghs, Andrey Tronin, Venkata Krishnan, J Kent Blasie, Koen Clays, William F. DeGrado, Jeffery G. Saven, and Michael J. Therien
A Computationally Designed Water-Soluble Variant of a G-Protein-Coupled Receptor: The Human Mu Opioid Receptor, Jose Manuel Perez Aguilar, Jin Xi, Felipe Matsunaga, Xu Cui, Bernard Selling, Jeffery G. Saven, and Renyu Liu
Submissions from 2012
NMR Structure and Dynamics of a Designed Water-Soluble Transmembrane Domain of Nicotinic Acetylcholine Receptor, Tanxing Cui, David Mowrey, Vasyl Bondarenko, Tommy Tillman, Dejian Ma, Elizabeth Landrum, Jose Manuel Perez Aguilar, Jing He, Wei Wang, Jeffery G. Saven, Roderic G. Eckenhoff, Pei Tang, and Yan Xu
Computational Design of a Protein Crystal, Christopher J Lanci, Christopher M MacDermaid, Seung-gu Keng, Rudresh Acharya, Benjamin North, Xi Yang, X Jade Qiu, William F. DeGrado, and Jeffery G. Saven
Binding Site and Affinity Prediction of General Anesthetics to Protein Targets Using Docking, Renyu Liu, Jose Manuel Perez Aguilar, David Liang, and Jeffery G. Saven
Computational Design of Membrane Proteins, Jose Manuel Perez Aguilar and Jeffery G. Saven
Human μ Opioid Receptor Models with Evaluation of the Accuracy Using the Crystal Structure of the Murine μ Opioid Receptor, Jose Manuel Perez Aguilar, Jeffery G. Saven, and Renyu Liu
Knowledge-Based Potential for Positioning Membrane-Associated Structures and Assessing Residue-Specific Energetic Contributions, Chaim A Schramm, Brett Thomas Hannigan, Jason E. Donald, Chen Keasar, Jeffery G. Saven, William F. DeGrado, and Ilan Samish
Submissions from 2011
Computational Protein Design to Re-Engineer Stromal Cell-Derived Factor-1α (SDF) Generates an Effective and Translatable Angiogenic Polypeptide Analog, William Hiesinger, Jose Manuel Perez Aguilar, Pavan Atluri, Nicole A. Marotta, John R. Frederick, J Raymond Fitzpatrick, Ryan C. McCormick, Jeffrey R. Muenzer, Elaine C. Yang, Rebecca D. Levit, Li-Jun Yuan, John W. Macarthur, Jeffery G. Saven, and Y Joseph Woo
Computational Protein Design: Engineering Molecular Diversity, Nonnatural Enzymes, Nonbiological Cofactor Complexes, and Membrane Proteins, Jeffery G. Saven
Submissions from 2010
Computational Design and Elaboration of a De Novo Heterotetrameric α-Helical Protein that Selectively Binds an Emissive Abiological (Porphinato)zinc Chromophore, H Christopher Fry, Andreas Lehmann, Jeffery G. Saven, William F. DeGrado, and Michael J. Therien
Computational Protein Design: Advances in the Design and Redesign of Biomolecular Nanostructures, Jeffery G. Saven
Submissions from 2009
Identification of the Active Form of Endothelial Lipase, a Homodimer in a Head-to-Tail Conformation, Nathalie Griffon, Weijin Jin, Thomas John Petty II, John Millar, Karen O. Badellino, Jeffery G. Saven, Dawn H. Marchadier, Ellis S. Kempner, Jeffrey Billheimer, Jane M. Glick, and Daniel J. Rader
Structural Coupling Between FKBP12 and Buried Water, Szilvia Szep, Sheldon Park, Eric T Boder, Gregory D Van Duyne, and Jeffery G. Saven
Characterization of Cofactor-Induced Folding Mechanism of a Zinc Binding Peptide Using Computationally Designed Mutants, Jia Tang, Seung-Gu Kang, Jeffery G. Saven, and Feng Gai
Submissions from 2008
Using α-Helical Coiled-Coils to Design Nanostructured Metalloporphyrin Arrays, Karen A. McAllister, Hongling Zou, Frank V. Cochran, Gretchen M Bender, Alessandro Senes, H Christopher Fry, Vikas Nanda, Patricia A. Keenan, James D. Lear, Jeffery G. Saven, Michael J. Therien, J Kent Blasie, and William F. DeGrado
Submissions from 2007
De Novo Design of a Single Chain Diphenylporphyrin Metalloprotein, Gretchen M Bender, Andreas Lehmann, Hongling Zou, Hong Cheng, H Christopher Fry, Don Engel, Michael J. Therien, J Kent Blasie, Heinrich Roder, Jeffery G. Saven, and William F. DeGrado
Fluorescence Correlation Spectroscopic Study of Serpin Depolymerization by Computationally Designed Peptides, Pramit Chowdhury, Wei Wang, Stacey Lavender, Michelle R Bunagan, Jason W. Klemke, Jia Tang, Jeffery G. Saven, Barry S. Cooperman, and Feng Gai
A Focused Antibody Library for Selecting scFvs Expressed at High Levels in the Cytoplasm, Pascal Philbert, Audrey Stoessel, Wei Wang, Annie-Paule Sibler, Nicole Bec, Christian Larroque, Jeffery G. Saven, Jérôme Courtête, Etienne Weiss, and Pierre Martineau
Submissions from 2004
Computational Design of Water-Soluble Analogues of the Potassium Channel KcsA, Avram Michael Slovic, Hidetoshi Kono, James D. Lear, Jeffery G. Saven, and William F. DeGrado
Submissions from 2001
Statistical Theory of Protein Combinatorial Libraries, Hidetoshi Kono, Jinming Zou, and Jeffery G. Saven