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Our group has previously demonstrated stent-based gene delivery with either viral or plasmid vectors. However, these previous studies utilized bulky PLGA or collagen stent coatings, known to cause inflammatory reactions in stented arteries. In the present experiments we successfully attached adenoviruses either directly, or via anti-adenovirus antibodies to the steel surface of stents using chemical coordination with biphosphonates.
This article is published under a Creative Commons Attribution-NonCommercial-NoDerivatives license (CC BY-NC-ND).
Fishbein, I., Alferiev, I. S., Wong, G., Vohs, J. M., Connolly, J. M., Wilensky, R. L., & Levy, R. J. (2003). An Ultra-Thin Polymer Coating for the Tethering of Adenoviral Vector to the Surface of Coronary Stents. Molecular Therapy, 7 (5, Supplement), S329-S330. http://dx.doi.org/10.1016/S1525-0016(16)41295-5
Date Posted: 01 December 2017
This document has been peer reviewed.