Document Type

Journal Article

Date of this Version

5-28-2012

Publication Source

Cancer and Clinical Oncology

Volume

1

Issue

2

Start Page

10

Last Page

24

DOI

10.5539/cco.v1n2p10

Abstract

Purpose: Ocular surface squamous neoplasia (OSSN) rate has increased in incidence with the HIV pandemic in Africa. Multiple factors including cellular and environmental can affect the pathogenesis of OSSN in HIV-infected patients. We will investigate anti-inflammatory cytokines, proinflammatory cytokines, and growth factor expression in sera and tissue samples of OSSN and pterygia for the potential link to the development of OSSN.

Results: Antibody analysis showed significant changes in levels of pro-inflammatory cytokines, anti-inflammatory cytokines and growth factors in sera. Quantitative RT-PCR of tissues showed expression of inflammatory cytokines and chemokines associated with HIV infection and carcinogenesis.

Conclusion: Our findings showed that dysregulation in expression of cytokines and growth factors in patients with multiple infections may contribute to pathogenesis of OSSN and pterygia. The data reinforces the significance of in depth analysis of immune function in HIV-1 OSSN patients with multiple viral infections that has potential for therapy and vaccine development.

Copyright/Permission Statement

This work is licensed under a Creative Commons Attribution 3.0 License.

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Date Posted: 29 July 2014

This document has been peer reviewed.