Induction of osteoblast differentiation markers in human dermal fibroblasts: potential application to bone tissue engineering.

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Departmental Papers (BE)
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Hee, Christopher K
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Tissue engineered constructs have the potential to be used as replacements for current bone graft technologies. One component necessary for bone tissue engineering is a readily available, osteogenic cell source. Human dermal fibroblasts may have the potential to differentiate along an osteoblastic lineage, making them a candidate for use in bone tissue engineering applications. The objective of this study was to validate the ability of dermal fibroblasts to express gene and protein markers of osteoblastic differentiation and to explore their potential, in combination with biomaterial scaffolds and signaling factors, for use in bone tissue engineering.

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2006-08-30
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Departmental Papers (BE)
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2023-05-17T02:02:35.000
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Copyright 2006 IEEE. Reprinted from Proceedings of the 28th IEEE Engineering in Medicine and Biology Science Annual International Conference, (EMBS 2006), August 2006, 4 pages. This material is posted here with permission of the IEEE. Such permission of the IEEE does not in any way imply IEEE endorsement of any of the University of Pennsylvania's products or services. Internal or personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution must be obtained from the IEEE by writing to pubs-permissions@ieee.org. By choosing to view this document, you agree to all provisions of the copyright laws protecting it.
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