For latest version: please go to https://academicentrepreneurship.pubpub.org/pub/wgdlxi2q/release/4 The process of developing a new therapeutic is long, expensive, and risky. Current small animal models are often poor representations of human disease, contributing to the high rate of failure in human trials. Outbred dogs can be excellent models for researching human disease. Clinical trials in dogs are inexpensive and efficient compared with human trials. Advaxis, a clinical-stage biotechnology company developing cancer immunotherapies, provides one case study on how trials in dogs can help advance trials in humans.