Department of Physics Papers

Document Type

Journal Article

Date of this Version

8-7-2007

Comments

Suggested Citation:
A. Gopinathan, K. Lee, J.M. Schwarz and A.J. Liu. (2007). Branching, Capping, and Severing in Dynamic Actin Structures. Physical Review Letters 99, 058103.

© 2007 The American Physical Society
http://dx.doi.org/10.1103/PhysRevLett.99.058103

Abstract

Branched actin networks at the leading edge of a crawling cell evolve via protein-regulated processes such as polymerization, depolymerization, capping, branching, and severing. A formulation of these processes is presented and analyzed to study steady-state network morphology. In bulk, we identify several scaling regimes in severing and branching protein concentrations and find that the coupling between severing and branching is optimally exploited for conditions in vivo. Near the leading edge, we find qualitative agreement with the in vivo morphology.

Date Posted: 12 May 2011

This document has been peer reviewed.