Departmental Papers (ESE)

Document Type

Journal Article

Date of this Version

May 2008

Comments

Copyright YEAR IEEE. Reprinted from Proceedings of the 9th International Workshop on Discrete Event Systems, pages 269-274.

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Abstract

We discuss the interplay between stochasticity and multistability in bio-molecular networks. The resulting cell-level stochastic behavior reflects the fundamentally discrete and random nature of the underlying molecular processes. These ideas are illustrated on the well studied example of the lac operon. We first describe the switching behavior predicted by a differential-equation based model and then show how cell-level stochastic behavior emerges. Finally we point out that the observed macroscopic behavior may not be enough to determine both the dynamic and stochastic parameters.

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Date Posted: 27 October 2008

This document has been peer reviewed.