Aim: To explore the available literature compiling studies that discuss patient related outcomes in terms of function and comfort for dental implants with fixed restorations. Materials and Methods: To identify studies relevant to the field of patient related outcomes in terms of function and comfort for treatment with dental implants in fixed restorations, literature review search was done via PubMed, Scopus, Ovid and Cochrane. Review articles were searched for any related studies that could be included in this systematic review. Results: 107 studies were initially identified from the search; 13 studies met the inclusion criteria and were selected for this systematic review. The analysis of the data related to comfort shows that the patients’ satisfaction ranged between 75.3% to 99.5% with an average of 90.8% and a standard error (SE) of ±2.6. Data analysis of the perception of function’s improvement showed that patients’ satisfaction ranged between 69.9% to 100% with an average of 92.1% and a standard error (SE) of ±2.4. Conclusion: The results indicate that the patient’s satisfaction in terms of function and comfort for treatment with dental implants and fixed restorations is relatively high and this is an acceptable modality of treatment. Further standardized studies with larger sample sizes and standardized evaluation scales are recommended.