Polymeric Scaffolds for Dental Pulp Tissue Engineering: A Review

Loading...
Thumbnail Image
Penn collection
Departmental Papers (Dental)
Degree type
Discipline
Subject
Polymer
Pulp
Regeneration
Scaffolds
Tissue engineering
Dental Pulp
Odontoblasts
Polymers
Regeneration
Tissue Engineering
Tissue Scaffolds
Cell engineering
Cytology
Natural polymers
Polymers
Pulp
Pulp materials
Scaffolds
Search engines
Stem cells
Tissue
Tissue engineering
Tissue regeneration
polymer
Biomaterial scaffolds
Fabrication method
Pulp regenerations
Regeneration
Scaffold fabrication
Stem cell differentiation
Synthetic polymers
Tissue engineering applications
odontoblast
regeneration
tissue engineering
tissue scaffold
tooth pulp
Scaffolds (biology)
Dental Materials
Dentistry
Endodontics and Endodontology
Oral and Maxillofacial Surgery
Oral Biology and Oral Pathology
Funder
Grant number
License
Copyright date
Distributor
Related resources
Author
Jazayeri, Hossein E.
Lee, Su-Min
Kuhn, Lauren
Fahimipour, Farahnaz
Tahriri, Mohammadreza
Tayebi, Lobat
Contributor
Abstract

Objectives: The purpose of this review is to describe recent developments in pulp tissue engineering using scaffolds and/or stem cells. It is crucial to understand how this approach can revitalize damaged dentin-pulp tissue. Widespread scaffold materials, both natural and synthetic, and their fabrication methods, and stem-progenitor cells with the potential of pulp regeneration will be discussed. Data and Sources: A review of literature was conducted through online databases, including MEDLINE by using the PubMed search engine, Scopus, and the Cochrane Library. Study Selection: Studies were selected based on relevance, with a preference given to recent research, particularly from the past decade. Conclusions: The use of biomaterial scaffolds and stem cells can be safe and potent for the regeneration of pulp tissue and re-establishment of tooth vitality. Natural and synthetic polymers have distinct advantages and limitations and in vitro and in vivo testing have produced positive results for cell attachment, proliferation, and angiogenesis. The type of biomaterial used for scaffold fabrication also facilitates stem cell differentiation into odontoblasts and the resulting biochemistry of tissue repair for each polymer and cell type was discussed. Multiple methods of scaffold design exist for pulp tissue engineering, which demonstrates the variability in tissue engineering applications in endodontics. This review explains the potential of evidence-based tissue engineering strategies and outcomes in pulp regeneration. © 2019 The Academy of Dental Materials

Advisor
Date Range for Data Collection (Start Date)
Date Range for Data Collection (End Date)
Digital Object Identifier
Series name and number
Publication date
2020-02-01
Journal title
Dental Materials
Volume number
Issue number
Publisher
Publisher DOI
Journal Issue
Comments
Recommended citation
Collection