An Intraoperative Glucose Control Benchmark for Formal Verification

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Departmental Papers (CIS)
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CPS Medical
Formal verification
Medical applications
Safety analysis
Closed-loop Controllers
Computer Engineering
Computer Sciences
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Abstract

Diabetes associated complications are affecting an increasingly large population of hospitalized patients. Since glucose physiology is significantly impacted by patient-specific parameters, it is critical to verify that a clinical glucose control protocol is safe across a wide patient population. A safe protocol should not drive the glucose level into dangerous low (hypoglycemia) or high (hyperglycemia) ranges. Verification of glucose controllers is challenging due to the high-dimensional, non-linear glucose physiological models which contain both unobservable states and unmeasurable patient-specific parameters. This paper presents a hybrid system model of a closed-loop physiological system that includes an existing FDA-accepted high-fidelity physiological model tailored to intraoperative settings and a validated improvement to a clinical glucose control protocol for diabetic cardiac surgery patients. We propose the closed-loop model as a physiological system benchmark for verification and present our initial results on verifying the system using the SMT-based hybrid system verification tool dReach.

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2015-10-01
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Departmental Papers (CIS)
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2023-05-17T12:19:22.000
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5th IFAC conference on Analysis and Design of Hybrid Systems (ADHS 2015)(http://adhs15.gatech.edu). Atlanta, USA, October 14-16, 2015
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