In honor of Dr. Harry L. Goldsmith's 75th birthday, we present a collection of articles from his collaborators and colleagues to commemorate Harry's outstanding contributions to the field of Biorheology. On any particular day, bioengineers around the world may find themselves fortunate enough to peer through a microscope to observe molecular or cellular level phenomena manifested before their eyes. Such observations of single molecule mechanics or blood flows or cellular deformation remind us of the power of clever experimental design and rigorous theoretical constructs as well as the complex beauty of dynamical systems in nature. In this spirit, the investigations reported in this issue of the Annals entitled Cellular Biorheology and Biomechanics have followed down many of the research paths pioneered by Dr. Harry Goldsmith.