Document Type

Technical Report

Date of this Version

6-2017

Publication Source

Blood Advances

Volume

1

Issue

14

Start Page

887

Last Page

898

DOI

10.1182/bloodadvances.2016003384

Abstract

Hematopoietic stem cells (HSCs) are characterized by their self-renewal potential and ability to differentiate into multiple blood lineages.1,2 They are essential for lifelong blood production and represent 1 of the best-studied somatic stem cell systems.2-4 Several decades of successful bone marrow transplants have demonstrated the therapeutic importance of HSCs.5 Much progress has been made to understand the regulatory network of HSC self-renewal and differentiation.6,7 Several studies suggest that epigenetic mechanisms play an important role in controlling HSC renewal and lineage commitment.8-12 Understanding the regulatory mechanisms of HSC self-renewal and differentiation is important for both basic stem cell biology and improving the quality of stem cell transplantation in clinical settings.

 

Date Posted:10 July 2017

This document has been peer reviewed.