Departmental Papers (BE)

Document Type

Journal Article

Date of this Version

December 2005

Comments

Postprint version. "This is a preprint of an article published in Journal of Biomedical Materials Research Part A, Volume 75A, Issue 4, 15 December 2005, pages 794-801."
Publisher URL: http://dx.doi.org/10.1002/jbm.a.30494

Abstract

A previous study demonstrated that the incorporation of bioactive glass (BG) into poly (lactic-co-glycolic acid) (PLGA) can promote the osteoblastic differentiation of marrow stromal cells (MSC) on PLGA by promote the formation of a calcium phosphate rich layer on its surface. To further understand the mechanisms underlying the osteogenic effect of PLGA-BG composite scaffolds, we tested whether solution-mediated factors derived from composite scaffolds/hybrids can promote osteogenesis of marrow stromal cells. The dissolution product from PLGA-30%BG scaffold stimulated osteogenesis of MSC, as was confirmed by increased mRNA expression of osteoblastic markers such as osteocalcin (OCN), alkaline phosphatase (ALP), and bone sialoprotein (BSP). The three-dimensional structure of the scaffolds may contribute to the production of cell derived factors which promoted distant MSC differentiation. Thus PLGABG composites demonstrates significant potential as a bone replacement material.

Keywords

poly (lactic-co-glycolic acid), bioactive glass, calcium phosphate, marrow stromal cells, osteogenesis

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Date Posted: 21 January 2006

This document has been peer reviewed.