Departmental Papers (BE)

Document Type

Conference Paper

Date of this Version

March 2003

Comments

Copyright 2003 IEEE. Reprinted from Proceedings of the 29th IEEE Annual Bioengineering Conference 2003, pages 156-157.
Publisher URL: http://ieeexplore.ieee.org/xpl/tocresult.jsp?isNumber=27351&page=5

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Abstract

Viruses are nano-scale pathogenic particles. Understanding viral attachment is important to understand infectivity, disease transmission, and virus propagation throughout the host. A new simulation technique has been developed to study viral docking behavior - Brownian Adhesive Dynamics (BRAD). BRAD couples Brownian motion algorithm with adhesive dynamic models, and incorporates the effect of virus/cell geometry - an improvement over previous models. The method is extendable to any virus/cell system as well as nanoparticle adhesion system. Current studies have focused on the HIV/CD4 cell system. Comparison of BRAD simulation predictions with those of previous models of viral ducking has shown differences in steady state bond number and bond trajectory. This indicates that geometry of the system plays a significant role in the bonding behavior of viruses. Thus, it is shown that the equivalent site hypothesis is suspect.

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Date Posted: 15 November 2004

This document has been peer reviewed.