Dissertations (BE)

The Department of Bioengineering, one of the first nationally, was established in 1973 with graduate degrees offered since 1961. Rated one of the top Bioengineering programs in the country, the Department presents the strong intellectual interdisciplinary infrastructure and collaborative culture that links Engineering, Life Sciences and Medicine at the University of Pennsylvania.

Theses and Dissertations from 2012

ICP-MS analysis of lanthanide-doped nanoparticles: A quantitative and multiplexing approach to investigate biodistribution, blood clearance, and targeting, Samuel Crayton

Microscale measurements of cell and tissue mechanics in three dimensions, Wesley R Legant

Theses and Dissertations from 2011

Identification of cell migratory cues by control of microenvironmental adhesion, Ravi Anand Desai

Inflammatory and neuronal mechanisms of facet-mediated pain in the context of neck injury, Ling Dong

Chemical and biological strategies for improving the sensitivity of SPIO-enhanced MR imaging, Andrew Elias

Auditory evoked gamma synchrony: Validating translational biomarkers for schizophrenia and autism, Michael Jeffrey Gandal

Chemical modifications to vesicle forming diblock copolymers: Development of smart functional polymersome membranes, Joshua S Katz

INDIRECT DETECTION OF AXONAL ARCHITECTURE WITH Q-SPACE IMAGING, Henry H. Ong

Enhancing Meniscus Repair through Biomaterial Design, Lara Ionescu Silverman

AN IN VITRO AND IN SILICO INVESTIGATION OF THE ROLE OF NMDA RECEPTOR SUBTYPES FOLLOWING MECHANICAL INJURY, Pallab Singh

Theses and Dissertations from 2008

Simulations of neutrophil rolling dynamics and the transition to firm adhesion, Kelly Elizabeth Caputo

Development and application of Tat-near-infrared-emissive polymersomes for in vivo optical imaging of dendritic cells, Natalie Aronson Christian

Dentate gyrus control of perforant path throughput to CA3 in a computational model, Stephen D Cranstoun

Engineering nanoparticle adhesive properties for selective targeting of cardiovascular disease, Jered Brackston Haun

Tendon mechanical properties and measures of shoulder function are altered after multiple tendon detachment in a rat rotator cuff model, Stephanie Perry

Interaction of excitatory and inhibitory synaptic inputs in neurons of the thalamocortical network during normal and pathological brain activity: Computational modeling and dynamic clamp in vitro, Ashlan Paige Reid

Theses and Dissertations from 2007

Identifying transcriptional regulatory modules and networks by integrative approaches, Guang Chen

Mechanics of head impact in infants, Brittany Coats

Herem in Biblical law and narrative, Mina Glick

Quantitative regional assessment of pulmonary parenchymal dynamics using image registration and analysis techniques, Tessa A Sundaram

Magnetic resonance studies of architecture and composition of bone, Aranee Techawiboonwong

Nanoscale particle binding in silico: HIV docking and multivalent recruitment under flow, Andrew Daniel Trister

Biophysical mechanisms for precise temporal signaling in the auditory system, John H. Wittig

ERK activation by integrin-mediated adhesion: A computational and experimental study, Ka Lai Yee

Theses and Dissertations from 2006

Circuit integration of afferent inputs in the hippocampus and its dysfunction in temporal lobe epilepsy, Chyze-Whee Ang

Learning in silicon: A neuromorphic model of the hippocampus, John Vernon Arthur

Perception of biological motion by intermediate-level motion features, Sandhitsu Das

Induction of osteoblastic proliferation and phenotype development with fibroblast growth factor 2: A kinetic and tissue culture evaluation of in vitro response in two and three dimensions, Melissa A Dupree

Molecular identity and hypercholesterolemia modulation of inwardly-rectifying potassium channels in endothelial cells, Yun Fang

Scarless healing in the fetus: Implications and strategies for postnatal tendon repair, Michele Favata

Effects of extracellular matrix compliance on cell morphology and function: Applications to the liver and central nervous system, Penelope Georges

Emissive polymer vesicles: Soft nanoscale probes for in vivo optical imaging, Paiman Peter Ghoroghchian

Nucleus pulposus degeneration and its role in intervertebral disc mechanical function, Wade Johannessen

Simulation of neutrophil adhesion under flow and the transition from rolling to firm adhesion, Ellen F Krasik

The combined effects of transmural pressure and axial strain on arterial remodeling ex vivo, Amanda Renee Lawrence

Synergistic hybrid image segmentation: Combining model and image-based strategies, Jiamin Liu

A silicon model of the primary visual cortex: Representing features through stochastic variations, Paul A Merolla

Dexamethasone -spermine as a local drug and gene delivery vehicle for improved pulmonary gene therapy, Amber Price

Traction forces exerted by endothelial cells on deformable substrates, Cynthia A Reinhart-King

Modeling the nonlinear active cochlea: Mathematics and analog VLSI, Bo Wen

Biomolecular localization: Applications in tissue engineering, William John Znidarsic

Theses and Dissertations from 2005

Polymersomes: From controlled release to anti-cancer, Fariyal Ahmed

Shape optimizing diffeomorphisms for medical image analysis, Brian B Avants

The role of cell kinematics and the N-methyl D-aspartate receptor in apoptosis and necrosis in the in vitro hippocampus following mechanical injury, Michael N DeRidder

Neutrophil adhesion dynamics during flow, Kathryn E Edmondson

Multi-component solution phase reaction microarrays for proteomic applications, Dhaval Gosalia

A nonlinear anisotropic continuum model of human annulus fibrosus mechanical behavior, Heather Anne Lynch Guerin

T channel dynamics in a silicon LGN, Kai Michael Hynna

Optimization of surface -immobilized peptide/protein presentation for control of the biological activity of substrates for tissue engineering applications, Mark H Lee

A novel device to measure long-term oxygen therapy use: Design and application for identifying adherence patterns, Sun-Kai Lin

Self -organizing neuromorphic systems with silicon growth cones, Brian Seisho Taba

Quantitative spin -lock magnetic resonance imaging: Technical development and biomedical applications, Andrew James Wheaton

Theses and Dissertations from 2004

Indirect detection of biological tissue microstructure by nuclear magnetic resonance microscopy, Chih-Liang Chin

Mechanisms and means of Na+-K+-ATPase activation during alveolar epithelial stretch, Jacob Lee Fisher

Investigation of the mechanical and biochemical stimuli of physiological and pathological remodeling in porcine saphenous veins ex vivo, Rebecca Jean Gusic Shaffer

Anti -inflammatory effects of hemodynamic shear stress: Roles for the glucocorticoid receptor and nitric oxide, Julie Ying Hui Ji

Development and utilization of a transgenic mouse injury model to investigate the role of interleukin-4 and interleukin-6 in tendon healing, Tony W Lin

Generalized scale: Theory, algorithms, and applications in image analysis, Anant Madabhushi

Probing the mechano-chemical transduction mechanism of skeletal muscle myosin II using a feedback enhanced optical trap, Yasuharu Takagi

Tissue engineering: Mechanical biological effects and functional reconstruction goals, Jun Yao

Airflow and odorant transport in the human nose: Implications for olfaction, Kai Zhao

Theses and Dissertations from 2003

Experimental and computational studies of selectin -mediated leukocyte adhesion, Sujata Kumari Bhatia

Automated analysis of determinants of wavefront propagation and block during fibrillatory conduction in the rabbit heart: A study using high resolution laser imaging and stereoscopic shape reconstruction, Robert Thomas Bove

Stretch -induced pulmonary alveolar epithelial barrier dysfunction, Kenneth Joseph Cavanaugh

Integration of the Gibbs prior model, the marching cubes method and the deformable model in medical image segmentation, Ting Chen

Contrast enhancement for diffuse optical spectroscopy and imaging: Phase cancellation and targeted fluorescence in cancer detection, Yu Chen

In vitro and in vivo evaluation of endothelial cells in microvascular networks, Alisha Lilly Sieminski

Theses and Dissertations from 2002

Bone tissue engineering in a rotating bioreactor: A quantitative approach, Edward Andrew Botchwey

Visualization and extraction of structural components from reconstructed volumes, Edgar Nat Garduno Angeles

In vivo magnetic resonance-based virtual bone biopsy, Bryon Roos Gomberg

Cationic corticosteroids for gene delivery and as controlled release antiinflammatory agents, Jeffrey Alan Miner Gruneich

Initiation and propagation of mechanically induced neuronal injury, Theresa Ann Gnade Lusardi

Biomechanics of traumatic brain injury in the infant, Michael Thomas Prange

Indirect 17O-magnetic resonance imaging of cerebral blood flow and oxidative metabolism, Dharmesh Ratilal Tailor

From the Philadelphia chromosome to the cytoskeleton: The role of BCR -ABL in modulating cell adhesion and initiating leukemia, Jason Albert Wertheim

Theses and Dissertations from 1996

Applications of the single path convection diffusion model of the human respiratory system, Joseph Daren Neff

Theses and Dissertations from 1995

Modeling retinal microcircuits for ganglion cells of different size, Christian K Kier

Theses and Dissertations from 1994

The biomechanics of the spinal cord during traumatic spinal cord injury, Lynne Eckert Bilston

Theses and Dissertations from 1993

Modeling and analysis of a Na$\sp+$ selective membrane, Jay Kevin Bass

Theses and Dissertations from 1992

Comparative rheological studies of the vitreous body of the eye, Belinda Lee

Catheter ablation of the heart using microwave energy, Mark Steven Mirotznik

Influence of airway structure on gas expirograms, Jeffrey D Schwardt

Large-transducer measurements of ultrasonic wavefront distortion in the female breast, Qing Zhu

Theses and Dissertations from 1991

Numerical modelling of respiratory and inert gas exchange in healthy human lungs, Sherif R Gobran

Triiodothyronine binding in the adult rat brain: A compartmental model approach, Monika Brigitte Schoenhoff

The dielectric properties of tissues, Susan Rae Smith-Baish

Theses and Dissertations from 1990

An interfacial approach to the mechanisms of passive dissolution of titanium in biological environments, Kevin Edward Healy

Theses and Dissertations from 1987

BIOMECHANICS OF TRAUMATIC COMA IN THE PRIMATE (HEAD INJURY), SUSAN SHEPS MARGULIES

A study of tree adjoining grammars, K Vijayashanker

Theses and Dissertations from 1983

MODELLING OF HEAT AND WATER VAPOR TRANSPORT IN THE HUMAN RESPIRATORY TRACT (AIR-CONDITIONING), LINDA MARIE HANNA

THE DIELECTRIC PROPERTIES OF FLUID SATURATED BONE, JEFFREY DAN KOSTERICH

Theses and Dissertations from 1982

DIELECTRIC STUDIES ON MICROEMULSIONS (OIL, WATER), BENJAMIN ROSS EPSTEIN

RADIO FREQUENCY CHARACTERISTICS OF MAMMALIAN TISSUES, RICHARD DEWAYNE STOY

Theses and Dissertations from 1981

TRANSPORT AND DEPOSITION OF HYGROSCOPIC AEROSOLS IN MODELS OF THE HUMAN BRONCHIAL TREE, FREDERICK RUSSELL HASELTON

THE MEASUREMENT AND ANALYSIS OF THE DIELECTRIC PROPERTIES OF NORMAL AND TUMOR TISSUES AT UHF AND MICROWAVE FREQUENCIES, JONATHAN LLOYD SCHEPPS

Theses and Dissertations from 1978

METAL BIOELECTRODE POLARIZATION: A FREQUENCY AND TIME DOMAIN ANALYSIS., BANU ONARAL